RHAG transports NH4+ from cytosol to extracellular region (red blood cells)

Stable Identifier
Reaction [transition]
Homo sapiens
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The human gene RHAG encodes a Rhesus blood group family type A glycoprotein which is expressed specifically in erythroid cells. It is thought to mediate ammonium export from these cells (Marini et al. 2000, Westhoff et al. 2002). Defects in RHAG are the cause of regulator type Rh-null hemolytic anemia (RHN, Rh-deficiency syndrome). RHN is a form of chronic hemolytic anemia (Hyland et al. 1998).

Literature References
PubMed ID Title Journal Year
9454778 A novel single missense mutation identified along the RH50 gene in a composite heterozygous Rhnull blood donor of the regulator type

Parkes, J, Chérif-Zahar, B, Cartron, JP, Saul, A, Hyland, CA, Cowley, N, Raynal, V

Blood 1998
11062476 The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast

Chérif-Zahar, B, André, B, Matassi, G, Cartron, JP, Marini, AM, Raynal, V

Nat Genet 2000
11861637 Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporter

Ferreri-Jacobia, M, Foskett, JK, Mak, DO, Westhoff, CM

J Biol Chem 2002
Catalyst Activity

ammonium transmembrane transporter activity of RHAG [plasma membrane]

Orthologous Events
Cross References
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