RHAG transports NH4+ from cytosol to extracellular region (red blood cells)

Stable Identifier
R-HSA-444416
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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RHAG transports NH4+ from cytosol to extracellular region (red blood cells)
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The human gene RHAG encodes a Rhesus blood group family type A glycoprotein which is expressed specifically in erythroid cells. It is thought to mediate ammonium export from these cells (Marini et al. 2000, Westhoff et al. 2002). Defects in RHAG are the cause of regulator type Rh-null hemolytic anemia (RHN, Rh-deficiency syndrome). RHN is a form of chronic hemolytic anemia (Hyland et al. 1998).
Literature References
PubMed ID Title Journal Year
9454778 A novel single missense mutation identified along the RH50 gene in a composite heterozygous Rhnull blood donor of the regulator type

Parkes, J, Chérif-Zahar, B, Cartron, JP, Saul, A, Hyland, CA, Cowley, N, Raynal, V

Blood 1998
11062476 The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast

Chérif-Zahar, B, André, B, Matassi, G, Cartron, JP, Marini, AM, Raynal, V

Nat Genet 2000
11861637 Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporter

Ferreri-Jacobia, M, Foskett, JK, Mak, DO, Westhoff, CM

J Biol Chem 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ammonium channel activity of RHAG [plasma membrane]

Physical Entity
RHAG [plasma membrane] (Homo sapiens)
Activity
ammonium channel activity (GO:0008519)
Orthologous Events
RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Bos taurus)
RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Caenorhabditis elegans)
RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Canis familiaris)
RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Danio rerio)
RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Dictyostelium discoideum)
RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Drosophila melanogaster)
RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Gallus gallus)
RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Mus musculus)
RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Rattus norvegicus)
RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Sus scrofa)
RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2009-10-23)
Reviewed
He, L  (2009-11-12)
Created
Jassal, B  (2009-10-23)
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