Reactome | RhCG mediates ammonium influx into kidney collecting duct cells

RhCG mediates ammonium influx into kidney collecting duct cells

Stable Identifier

R-HSA-444393

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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RhCG mediates ammonium influx into kidney collecting duct cells

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The human gene RhCG encodes the Rhesus blood group family type C glycoprotein which is mainly expressed in kidney collecting duct but also found in testis. RhCG is located on the apical membrane and mediates the bi-directional transport of ammonium into and out of renal collecting duct cells in an electroneutral manner, with H+ transported the other way (Liu Z et al, 2000; Marini AM et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
11062476	The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast Chérif-Zahar, B, André, B, Matassi, G, Cartron, JP, Marini, AM, Raynal, V	Nat Genet	2000
10852913	Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis Cheng, JF, Mo, R, Liu, Z, Hui, C, Mohandas, N, Chen, Y, Huang, CH	J Biol Chem	2000