RhCG mediates ammonium influx into kidney collecting duct cells

Stable Identifier
Reaction [transition]
Homo sapiens
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The human gene RhCG encodes the Rhesus blood group family type C glycoprotein which is mainly expressed in kidney collecting duct but also found in testis. RhCG is located on the apical membrane and mediates the bi-directional transport of ammonium into and out of renal collecting duct cells in an electroneutral manner, with H+ transported the other way (Liu Z et al, 2000; Marini AM et al, 2000).

Literature References
PubMed ID Title Journal Year
11062476 The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast

Chérif-Zahar, B, André, B, Matassi, G, Cartron, JP, Marini, AM, Raynal, V

Nat Genet 2000
10852913 Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis

Cheng, JF, Mo, R, Liu, Z, Hui, C, Mohandas, N, Chen, Y, Huang, CH

J Biol Chem 2000
Event Information
Catalyst Activity

ammonium transmembrane transporter activity of RHCG [plasma membrane]

Orthologous Events
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