RhCG mediates ammonium influx into kidney collecting duct cells

Stable Identifier
R-HSA-444393
Type
Reaction [transition]
Species
Homo sapiens
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The human gene RhCG encodes the Rhesus blood group family type C glycoprotein which is mainly expressed in kidney collecting duct but also found in testis. RhCG is located on the apical membrane and mediates the bi-directional transport of ammonium into and out of renal collecting duct cells in an electroneutral manner, with H+ transported the other way (Liu Z et al, 2000; Marini AM et al, 2000).

Literature References
PubMed ID Title Journal Year
10852913 Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis

Liu, Z, Chen, Y, Mo, R, Hui, C, Cheng, JF, Mohandas, N, Huang, CH

J Biol Chem 2000
11062476 The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast

Marini, AM, Matassi, G, Raynal, V, André, B, Cartron, JP, Chérif-Zahar, B

Nat Genet 2000
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Catalyst Activity
Title
ammonium transmembrane transporter activity of RHCG [plasma membrane]
Physical Entity
Activity
Orthologous Events
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