Reactome | MLNR (GPR38) is a receptor for motilin

MLNR (GPR38) is a receptor for motilin

Stable Identifier

R-HSA-444208

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Motilin is a 22-amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract of humans and other species. It affects gastric motility by stimulating interdigestive antrum and duodenal contractions. The receptor protein is known as motilin receptor, derived from the gene MLNR (first identified as GPR38).

Literature References

PubMed ID	Title	Journal	Year
10381885	Receptor for motilin identified in the human gastrointestinal system Feighner, SD, Tan, CP, McKee, KK, Palyha, OC, Hreniuk, DL, Pong, SS, Austin, CP, Figueroa, D, MacNeil, D, Cascieri, MA, Nargund, R, Bakshi, R, Abramovitz, M, Stocco, R, Kargman, S, O'Neill, G, Van Der Ploeg, LH, Evans, J, Patchett, AA, Smith, RG, Howard, AD	Science	1999