Receptor FFAR2 binds carboxylates

Stable Identifier
R-HSA-444171
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Free fatty acid receptor 2 (FFAR2/GPR43) is activated by carboxylate ligands, with relative potencies as follows: acetate = propionate = butyrate > pentanoate > hexanoate = formate.

Literature References
PubMed ID Title Journal Year
12496283 The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

Brown, AJ, Goldsworthy, SM, Barnes, AA, Eilert, MM, Tcheang, L, Daniels, D, Muir, AI, Wigglesworth, MJ, Kinghorn, I, Fraser, NJ, Pike, NB, Strum, JC, Steplewski, KM, Murdock, PR, Holder, JC, Marshall, FH, Szekeres, PG, Wilson, S, Ignar, DM, Foord, SM, Wise, A, Dowell, SJ

J Biol Chem 2003
Participants
Participant Of
Orthologous Events
Authored
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Created