Reactome | VMAT1/2 can mediate the transport of biogenic amines

VMAT1/2 can mediate the transport of biogenic amines

Stable Identifier

R-HSA-444160

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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VMAT1/2 can mediate the transport of biogenic amines

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The human gene SLC18A1 encodes the vesicular monoamine transporter 1 (VMAT1) (Erickson JD et al, 1996). VMAT1 is mainly expressed in neuroendocrine cells. The human gene SLC18A2 encodes VMAT2 (Erickson JD and Eiden LE, 1993). Both transporters can mediate the transport of biogenic amines into secretory vesicles, which can then discharge their contents into the extracellular space by exocytosis. Predominant biogenic amines these proteins can transport are serotonin, dopamine, adrenaline, noradrenaline and histamine.

Literature References

PubMed ID	Title	Journal	Year
8643547	Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter Eiden, LE, Weihe, E, Erickson, JD, Schafer, MK, Bonner, TI	Proc Natl Acad Sci U S A	1996
8245983	Functional identification and molecular cloning of a human brain vesicle monoamine transporter Eiden, LE, Erickson, JD	J Neurochem	1993