VMAT1/2 can mediate the transport of biogenic amines

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R-HSA-444160
Type
Reaction [transition]
Species
Homo sapiens
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The human gene SLC18A1 encodes the vesicular monoamine transporter 1 (VMAT1) (Erickson JD et al, 1996). VMAT1 is mainly expressed in neuroendocrine cells. The human gene SLC18A2 encodes VMAT2 (Erickson JD and Eiden LE, 1993). Both transporters can mediate the transport of biogenic amines into secretory vesicles, which can then discharge their contents into the extracellular space by exocytosis. Predominant biogenic amines these proteins can transport are serotonin, dopamine, adrenaline, noradrenaline and histamine.

Literature References
PubMed ID Title Journal Year
8245983 Functional identification and molecular cloning of a human brain vesicle monoamine transporter

Erickson, JD, Eiden, LE

J Neurochem 1993
8643547 Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter

Erickson, JD, Schafer, MK, Bonner, TI, Eiden, LE, Weihe, E

Proc Natl Acad Sci U S A 1996
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Catalyst Activity
Title
monoamine transmembrane transporter activity of VMAT1/2 [clathrin-sculpted monoamine transport vesicle membrane]
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Orthologous Events
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