VMAT1/2 can mediate the transport of biogenic amines

Stable Identifier
Reaction [transition]
Homo sapiens
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The human gene SLC18A1 encodes the vesicular monoamine transporter 1 (VMAT1) (Erickson JD et al, 1996). VMAT1 is mainly expressed in neuroendocrine cells. The human gene SLC18A2 encodes VMAT2 (Erickson JD and Eiden LE, 1993). Both transporters can mediate the transport of biogenic amines into secretory vesicles, which can then discharge their contents into the extracellular space by exocytosis. Predominant biogenic amines these proteins can transport are serotonin, dopamine, adrenaline, noradrenaline and histamine.

Literature References
PubMed ID Title Journal Year
8643547 Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter

Eiden, LE, Weihe, E, Erickson, JD, Schafer, MK, Bonner, TI

Proc Natl Acad Sci U S A 1996
8245983 Functional identification and molecular cloning of a human brain vesicle monoamine transporter

Eiden, LE, Erickson, JD

J Neurochem 1993
Catalyst Activity

monoamine transmembrane transporter activity of VMAT1/2 [clathrin-sculpted monoamine transport vesicle membrane]

Orthologous Events
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