Reactome | SLC18A1 [clathrin-sculpted monoamine transport vesicle membrane]

SLC18A1 [clathrin-sculpted monoamine transport vesicle membrane]

Stable Identifier

R-HSA-444153

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-sculpted monoamine transport vesicle membrane

Synonyms

VMAT1, Chromaffin granule amine transporter, VMAT1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P54219 SLC18A1

Gene Names

SLC18A1, VAT1, VMAT1

Chain

chain:1-525

Reference Genes

BioGPS Gene:6570 P542193

COSMIC (genes):SLC18A1 SLC18A1

COSMIC (genes):VAT1 SLC18A1

CTD Gene:6570 P542193

dbSNP Gene:6570 P542193

ENSEMBL:ENSG00000036565 VAT1

HGNC:10934 P542193

KEGG:hsa:6570 P542193

Monarch:6570 P542193

NCBI Gene:6570 P542193

OMIM:193002 P542193

UCSC:P54219 P542193

Reference Transcript

Participates

as a member of

VMAT1/2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)

Inferred To

cat-1 [clathrin-sculpted monoamine transport vesicle membrane] (Caenorhabditis elegans)

Homologues of SLC18A1 [clathrin-sculpted monoamine transport vesicle membrane] (Xenopus tropicalis)

LOC100495571 [clathrin-sculpted monoamine transport vesicle membrane] (Xenopus tropicalis)

LOC100496053 [clathrin-sculpted monoamine transport vesicle membrane] (Xenopus tropicalis)

Slc18a1 [clathrin-sculpted monoamine transport vesicle membrane] (Mus musculus)

Slc18a1 [clathrin-sculpted monoamine transport vesicle membrane] (Rattus norvegicus)

slc18a2 [clathrin-sculpted monoamine transport vesicle membrane] (Xenopus tropicalis)

SLC18A1 [clathrin-sculpted monoamine transport vesicle membrane] (Bos taurus)

SLC18A1 [clathrin-sculpted monoamine transport vesicle membrane] (Canis familiaris)

SLC18A1 [clathrin-sculpted monoamine transport vesicle membrane] (Gallus gallus)

SLC18A1 [clathrin-sculpted monoamine transport vesicle membrane] (Schizosaccharomyces pombe)

SLC18A1 [clathrin-sculpted monoamine transport vesicle membrane] (Sus scrofa)

Vmat [clathrin-sculpted monoamine transport vesicle membrane] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

1011

OpenTargets

ENSG00000036565

ENSEMBL

ENST00000265808, ENSP00000413361, ENSP00000387549, ENST00000276373, ENST00000519026, ENSP00000371021, ENST00000381608, ENST00000440926, ENSG00000036565, ENSP00000276373, ENSP00000429664, ENSP00000265808, ENST00000437980

HPA

ENSG00000036565-SLC18A1

GeneCards

SLC18A1

ZINC - Substances

VMAT1_HUMAN

ZINC target

P54219

PRO

P54219

Pharos - Targets

P54219

GlyGen

P54219

PDB

8TGK, 8TGM, 8TGN, 8TGL, 8TGI, 8TGG, 8TGH, 8TGJ

HMDB Protein

HMDBP03857

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60427 FADS1	1	FADS1 [endoplasmic reticulum membrane] (R-HSA-400122)	0.527	2
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
UniProt:Q96BN8 OTULIN	1	OTULIN [cytosol] (R-HSA-5661503)	0.527	2
UniProt:Q99808 SLC29A1	1	SLC29A1 [plasma membrane] (R-HSA-54335)	0.527	2
UniProt:Q7L8W6 DPH6	1	DPH6 [cytosol] (R-HSA-5358469)	0.527	2

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