PROT mediates L-proline uptake

Stable Identifier
R-HSA-444100
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The amino acid L-proline can act as a neurotransmitter. Its actions are terminated by its re-uptake from the synaptic cleft into the pre-synaptic terminal in the brain. This re-uptake is mediated by a sodium-dependent proline transporter, PROT (Shafqat S et al, 1995).

Literature References
PubMed ID Title Journal Year
7651355 Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes

Shafqat, S, Velaz-Faircloth, M, Henzi, VA, Whitney, KD, Yang-Feng, TL, Seldin, MF, Fremeau RT, Jr

Mol Pharmacol 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
proline:sodium symporter activity of SLC6A7 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
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Created
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