PROT mediates L-proline uptake

Stable Identifier
R-HSA-444100
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PROT mediates L-proline uptake
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The amino acid L-proline can act as a neurotransmitter. Its actions are terminated by its re-uptake from the synaptic cleft into the pre-synaptic terminal in the brain. This re-uptake is mediated by a sodium-dependent proline transporter, PROT (Shafqat S et al, 1995).
Literature References
PubMed ID Title Journal Year
7651355 Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes

Shafqat, S, Velaz-Faircloth, M, Seldin, MF, Henzi, VA, Yang-Feng, TL, Fremeau RT, Jr, Whitney, KD

Mol Pharmacol 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

proline:sodium symporter activity of SLC6A7 [plasma membrane]

Physical Entity
SLC6A7 [plasma membrane] (Homo sapiens)
Activity
proline:sodium symporter activity (GO:0005298)
Orthologous Events
PROT mediates L-proline uptake (Bos taurus)
PROT mediates L-proline uptake (Caenorhabditis elegans)
PROT mediates L-proline uptake (Canis familiaris)
PROT mediates L-proline uptake (Drosophila melanogaster)
PROT mediates L-proline uptake (Gallus gallus)
PROT mediates L-proline uptake (Mus musculus)
PROT mediates L-proline uptake (Plasmodium falciparum)
PROT mediates L-proline uptake (Rattus norvegicus)
PROT mediates L-proline uptake (Sus scrofa)
PROT mediates L-proline uptake (Xenopus tropicalis)
Authored
Jassal, B  (2009-10-22)
Reviewed
He, L  (2009-11-12)
Created
Jassal, B  (2009-10-22)
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