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SLC6A1 [plasma membrane]
Stable Identifier
R-HSA-444027
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sodium- and chloride-dependent GABA transporter 1, SC6A1_HUMAN
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
Reuptake of GABA (Homo sapiens)
GAT1-3 mediate Na+/Cl- dependent GABA transport (Homo sapiens)
SLC6A GABA transporters [plasma membrane] (Homo sapiens)
SLC6A1 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
GAT1-3 mediate Na+/Cl- dependent GABA transport (Homo sapiens)
SLC6A GABA transporters [plasma membrane] (Homo sapiens)
SLC6A1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30531 SLC6A1
Gene Names
SLC6A1, GABATR, GABT1, GAT1
Chain
chain:1-599
Reference Genes
BioGPS Gene:6529 SLC6A1
COSMIC (genes):SLC6A1 SLC6A1
CTD Gene:6529 SLC6A1
dbSNP Gene:6529 SLC6A1
ENSEMBL:ENSG00000157103 SLC6A1
HGNC:11042 SLC6A1
KEGG:hsa:6529 SLC6A1
Monarch:6529 SLC6A1
NCBI Gene:6529 SLC6A1
OMIM:137165 SLC6A1
UCSC:P30531 SLC6A1
Reference Transcript
RefSeq:NM_001348250.1 SLC6A1
RefSeq:XM_011534027.2 SLC6A1
RefSeq:XM_011534025.2 SLC6A1
RefSeq:XM_005265411.4 SLC6A1
RefSeq:XM_005265410.4 SLC6A1
RefSeq:XM_017007072.1 SLC6A1
RefSeq:NM_003042.3 SLC6A1
RefSeq:XM_017007071.1 SLC6A1
Other Identifiers
11723862_at
11747129_a_at
16937645
205152_PM_at
205152_at
2610635
2610640
2610641
2610642
2610643
2610644
2610645
2610646
2610647
2610648
2610649
2610650
2610651
2610652
2610653
2610654
2610655
2610656
2610657
2610658
2610659
2610660
2610661
2610662
2610663
2610664
2610665
2610666
2610667
2610668
2610669
2610670
2610671
2610672
2610673
2610674
2610675
2610676
2610677
2610678
2610679
2610680
2610681
2610682
42987_at
6529
8077833
A_14_P137618
A_23_P166758
A_24_P268685
GE59797
GO:0003013
GO:0005215
GO:0005332
GO:0005515
GO:0005886
GO:0006836
GO:0006865
GO:0007268
GO:0007612
GO:0007613
GO:0008306
GO:0009636
GO:0009744
GO:0009986
GO:0010288
GO:0014054
GO:0014070
GO:0014074
GO:0015185
GO:0015293
GO:0015378
GO:0015812
GO:0016020
GO:0022857
GO:0023052
GO:0030424
GO:0032229
GO:0032355
GO:0034330
GO:0035725
GO:0042220
GO:0042734
GO:0042802
GO:0042995
GO:0043025
GO:0045202
GO:0045211
GO:0046872
GO:0050808
GO:0050877
GO:0051592
GO:0051936
GO:0051939
GO:0055085
GO:0098658
GO:0098719
GO:0098793
GO:0098810
GO:0098982
GO:0150104
GO:1902476
GO:1904313
HMNXSV003051171
Hs.22003.0.S2_3p_at
ILMN_1744191
ILMN_2171588
PH_hs_0031062
TC03000063.hg
X54673_at
Participates
as a member of
SLC6A GABA transporters [plasma membrane] (Homo sapiens)
Inferred To
SLC6A1 [plasma membrane]
(Bos taurus)
SLC6A1 [plasma membrane]
(Caenorhabditis elegans)
SLC6A1 [plasma membrane]
(Canis familiaris)
SLC6A1 [plasma membrane]
(Danio rerio)
SLC6A1 [plasma membrane]
(Drosophila melanogaster)
SLC6A1 [plasma membrane]
(Gallus gallus)
SLC6A1 [plasma membrane]
(Mus musculus)
SLC6A1 [plasma membrane]
(Plasmodium falciparum)
SLC6A1 [plasma membrane]
(Rattus norvegicus)
SLC6A1 [plasma membrane]
(Sus scrofa)
SLC6A1 [plasma membrane]
(Xenopus tropicalis)
Homologues of SLC6A1 [plasma membrane]
(Plasmodium falciparum)
Cross References
RefSeq
NP_001335179.1
,
XP_016862560.1
,
XP_011532329.1
,
NP_003033.3
,
XP_016862561.1
,
XP_005265468.1
,
XP_011532327.1
,
XP_005265467.1
Guide to Pharmacology - Targets
929
ENSEMBL
ENSP00000494050
,
ENST00000645029
,
ENSP00000494134
,
ENSP00000494136
,
ENSP00000287766
,
ENSP00000494997
,
ENSP00000496238
,
ENST00000642767
,
ENSP00000495900
,
ENSP00000496619
,
ENST00000646570
,
ENSP00000494778
,
ENST00000642820
,
ENST00000646924
,
ENSG00000157103
,
ENSP00000495751
,
ENSP00000493591
,
ENST00000645974
,
ENST00000642201
,
ENST00000287766
,
ENSP00000496064
,
ENSP00000496302
,
ENST00000643396
,
ENST00000646702
,
ENST00000643498
,
ENSP00000496348
,
ENSP00000494346
,
ENST00000646022
,
ENST00000645592
,
ENST00000642639
,
ENST00000642735
,
ENST00000647194
,
ENST00000645054
,
ENST00000646060
,
ENST00000642515
,
ENSP00000494191
,
ENSP00000496390
,
ENSP00000496697
,
ENSP00000496171
OpenTargets
ENSG00000157103
ZINC - FDA approved
SC6A1_HUMAN
ZINC - Substances
SC6A1_HUMAN
ZINC - Biogenic
SC6A1_HUMAN
ZINC target
P30531
PRO
P30531
GlyGen
P30531
PDB
7Y7W
,
7Y7Z
,
7Y7Y
,
7SK2
,
7Y7V
ZINC - Investigational
SC6A1_HUMAN
ZINC - Metabolites
SC6A1_HUMAN
GeneCards
SLC6A1
HPA
ENSG00000157103-SLC6A1
Pharos - Targets
P30531
Orphanet
SLC6A1
ZINC - Predictions - Purchasable
SC6A1_HUMAN
HMDB Protein
HMDBP02813
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H3Z4 DNAJC5
5
DNAJC5 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-9659623)
DNAJC5 [azurophil granule membrane]
(R-HSA-6799144)
DNAJC5 [specific granule membrane]
(R-HSA-6800990)
DNAJC5 [plasma membrane]
(R-HSA-936512)
DNAJC5 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888598)
0.471
2
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