Receptor ACKR2 binds most inflammatory CC chemokines

Stable Identifier
R-HSA-443986
Type
Reaction [binding]
Species
Homo sapiens
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Atypical chemokine receptor 2 (ACKR2, CCBP2, D6) is a promiscuous chemokine receptor which has no known signalling function and is therefore considered to be a 'silent' or 'scavenger' receptor. ACKR2 negatively regulates inflammatory responses by binding CC chemokines, targeting them for degradation following receptor internalization (Fra et al. 2003, Bonecchi et al. 2004, Graham & Locati 2013).

Literature References
PubMed ID Title Journal Year
15067078 Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor

Bonecchi, R, Locati, M, Galliera, E, Vulcano, M, Sironi, M, Fra, AM, Gobbi, M, Vecchi, A, Sozzani, S, Haribabu, B, van Damme, J, Mantovani, A

J Immunol 2004
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