Reactome | FZD6 [plasma membrane]

FZD6 [plasma membrane]

Stable Identifier

R-HSA-443950

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Frizzled-6, FZD6_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by WNT in cancer (Homo sapiens)
    - Signaling by RNF43 mutants (Homo sapiens)
      - RNF43 frameshift mutants show enhanced WNT siganling (Homo sapiens)
        
        N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
        
        FZD [plasma membrane] (Homo sapiens)
        
        FZD6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60353 FZD6

Gene Names

FZD6

Chain

signal peptide:1-18, chain:19-706

Reference Genes

BioGPS Gene:8323 FZD6

COSMIC (genes):FZD6 FZD6

CTD Gene:8323 FZD6

dbSNP Gene:8323 FZD6

ENSEMBL:ENSG00000164930.12 FZD6

HGNC:4044 FZD6

KEGG Gene (Homo sapiens):8323 FZD6

Monarch:8323 FZD6

NCBI Gene:8323 FZD6

OMIM:603409 FZD6

UCSC:O60353 FZD6

Reference Transcript

Other Identifiers

11739302_a_at

11749125_a_at

17071625

203987_PM_at

203987_at

3110273

3110274

3110275

3110276

3110277

3110278

3110284

3110286

3110287

3110288

3110289

3110295

3110297

3110298

3110299

3110302

3110303

3110304

34472_at

47968_at

8147766

8323

A_14_P118822

A_23_P123276

GE53324

GO:0001736

GO:0001843

GO:0001942

GO:0004888

GO:0004930

GO:0005515

GO:0005783

GO:0005789

GO:0005886

GO:0006351

GO:0006355

GO:0007165

GO:0007166

GO:0007186

GO:0009986

GO:0016020

GO:0016021

GO:0016055

GO:0016324

GO:0016327

GO:0017147

GO:0023052

GO:0030168

GO:0030659

GO:0030901

GO:0031410

GO:0031625

GO:0033278

GO:0035567

GO:0035880

GO:0042060

GO:0042472

GO:0042813

GO:0043226

GO:0043433

GO:0045177

GO:0048105

GO:0048856

GO:0060070

GO:0060071

GO:0060089

GO:0090090

GO:1904693

HMNXSV003006632

ILMN_1659297

TC08000645.hg

g4503830_3p_at

Participates

as a candidate of

as a member of

WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)

Other forms of this molecule

ub-FZD6 [plasma membrane]

Inferred To

Fzd6 [plasma membrane] (Mus musculus)

Fzd6 [plasma membrane] (Rattus norvegicus)

fz [plasma membrane] (Drosophila melanogaster)

mom-5 [plasma membrane] (Caenorhabditis elegans)

fzd6 [plasma membrane] (Xenopus tropicalis)

FZD6 [plasma membrane] (Bos taurus)

FZD6 [plasma membrane] (Canis familiaris)

FZD6 [plasma membrane] (Danio rerio)

FZD6 [plasma membrane] (Gallus gallus)

FZD6 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001158087.1, NP_001158088.1, NP_003497.2, NP_001304725.1

Guide to Pharmacology - Targets

234

OpenTargets

ENSG00000164930

HPA

ENSG00000164930-FZD6

GeneCards

O60353

Ensembl

ENSP00000429528, ENST00000522566, ENST00000523739, ENSP00000351605, ENSG00000164930, ENSP00000429055, ENST00000358755

PRO

O60353

Pharos - Targets

O60353

Orphanet

20492

HMDB Protein

HMDBP07702