TXA2 is hydrolysed to TXB2

Stable Identifier
R-HSA-443894
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Thromboxane A2 degenerates to thromboxane B2
ReviewStatus
5/5
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TXA2 is hydrolysed to TXB2
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Thromboxane A2 (TXA2) contains an unstable ether linkage that is rapidly hydrolysed under aqueous conditions to form the biologically inert thromboxane B2 (TXB2) (Wang et al. 2001, Hamberg et al. 1975), which is excreted.
Literature References
PubMed ID Title Journal Year
11297515 Substrate binding is the rate-limiting step in thromboxane synthase catalysis

Tsai, AL, Wang, LH, Hsu, PY

J Biol Chem 2001
1059088 Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides

Hamberg, M, Samuelsson, B, Svensson, J

Proc Natl Acad Sci U S A 1975
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Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Jupe, S  (2009-10-14)
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