Reactome | KIF4B [cytosol]

KIF4B [cytosol]

Stable Identifier

R-HSA-443855

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Chromosome-associated kinesin KIF4B, KIF4B_HUMAN

Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Factors involved in megakaryocyte development and platelet production (Homo sapiens)
  - Kinesins (Homo sapiens)
    - Chromokinesins form dimers (Homo sapiens)
      - Chromokinesin dimers [cytosol] (Homo sapiens)
        
        Kinesin-4 homodimers [cytosol] (Homo sapiens)
        
        KIF4B homodimer [cytosol] (Homo sapiens)
        
        KIF4B [cytosol] (Homo sapiens)
      - Chromokinesin monomers [cytosol] (Homo sapiens)
        
        KIF4 [cytosol] (Homo sapiens)
        
        KIF4B [cytosol] (Homo sapiens)
    - Kinesins bind microtubules (Homo sapiens)
      - Kinesins [cytosol] (Homo sapiens)
        
        Chromokinesin dimers [cytosol] (Homo sapiens)
        
        Kinesin-4 homodimers [cytosol] (Homo sapiens)
        
        KIF4B homodimer [cytosol] (Homo sapiens)
        
        KIF4B [cytosol] (Homo sapiens)
      - Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Chromokinesin dimers [cytosol] (Homo sapiens)
        
        Kinesin-4 homodimers [cytosol] (Homo sapiens)
        
        KIF4B homodimer [cytosol] (Homo sapiens)
        
        KIF4B [cytosol] (Homo sapiens)
    - Kinesins move along microtubules consuming ATP (Homo sapiens)
      - Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Chromokinesin dimers [cytosol] (Homo sapiens)
        
        Kinesin-4 homodimers [cytosol] (Homo sapiens)
        
        KIF4B homodimer [cytosol] (Homo sapiens)
        
        KIF4B [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Chromokinesin dimers [cytosol] (Homo sapiens)
        
        Kinesin-4 homodimers [cytosol] (Homo sapiens)
        
        KIF4B homodimer [cytosol] (Homo sapiens)
        
        KIF4B [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Chromokinesin dimers [cytosol] (Homo sapiens)
        
        Kinesin-4 homodimers [cytosol] (Homo sapiens)
        
        KIF4B homodimer [cytosol] (Homo sapiens)
        
        KIF4B [cytosol] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Chromokinesin dimers [cytosol] (Homo sapiens)
        
        Kinesin-4 homodimers [cytosol] (Homo sapiens)
        
        KIF4B homodimer [cytosol] (Homo sapiens)
        
        KIF4B [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Chromokinesin dimers [cytosol] (Homo sapiens)
        
        Kinesin-4 homodimers [cytosol] (Homo sapiens)
        
        KIF4B homodimer [cytosol] (Homo sapiens)
        
        KIF4B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q2VIQ3 KIF4B

Gene Names

KIF4B

Chain

chain:1-1234

Reference Genes

BioGPS Gene:285643 KIF4B

COSMIC (genes):KIF4B KIF4B

CTD Gene:285643 KIF4B

dbSNP Gene:285643 KIF4B

ENSEMBL:ENSG00000226650 KIF4B

HGNC:6322 KIF4B

KEGG:hsa:285643 KIF4B

Monarch:285643 KIF4B

NCBI Gene:285643 KIF4B

OMIM:609184 KIF4B

UCSC:Q2VIQ3 KIF4B

Reference Transcript

RefSeq:NM_001099293.2 KIF4B

Other Identifiers

11737197_s_at

16991460

2836919

2836920

2836921

2836922

2836923

2836924

2836925

285643

3980561

3980562

3980568

3980569

3980570

3980573

3980574

3980575

3980576

3980580

3980582

3980587

3980593

3980594

3980595

3980598

3980604

3980605

3980606

3980608

3980609

8109484

GE493050

GO:0000281

GO:0000910

GO:0003677

GO:0003774

GO:0003777

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0005875

GO:0007010

GO:0007018

GO:0007052

GO:0008017

GO:0008092

GO:0016363

GO:0043226

GO:0046872

GO:0051231

GO:0051256

GO:0051536

GO:0140657

HMNXSV003044159

PH_hs_0033716

TC05000858.hg

Participates

as a component of

KIF4B homodimer [cytosol] (Homo sapiens)

as a member of

KIF4 [cytosol] (Homo sapiens)

Inferred To

Homologues of KIF4B [cytosol] (Rattus norvegicus)

KIF4B [cytosol] (Bos taurus)

KIF4B [cytosol] (Canis familiaris)

KIF4B [cytosol] (Danio rerio)

KIF4B [cytosol] (Drosophila melanogaster)

KIF4B [cytosol] (Gallus gallus)

KIF4B [cytosol] (Mus musculus)

KIF4B [cytosol] (Rattus norvegicus)

KIF4B [cytosol] (Sus scrofa)

KIF4B [cytosol] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000435029, ENSG00000226650, ENSP00000387875

OpenTargets

ENSG00000226650

GeneCards

KIF4B

HPA

ENSG00000226650-KIF4B

PRO

Q2VIQ3

Pharos - Targets

Q2VIQ3

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