Reactome | Interaction of NUMB with L1

Interaction of NUMB with L1

Stable Identifier

R-HSA-443783

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Numb is thought to be a phosphotyrosine binding (PTB) domain containing cargo specific adaptor protein, which links specific cargo to the endocytic machinery. It associates with collapsin response mediator protein-2 (CRMP 2) with its PTB domain and alpha adaptin (a subunit of the AP 2 adaptor complex) through its tripeptide Asp-Pro-Phe (DPF) motif, and is involved in clathrin dependent endocytosis at the plasma membrane. Numb is associated with L1 under physiological conditions and functions in endocytosis of L1 in the C domain membrane of axonal growth cones.

Literature References

PubMed ID	Title	Journal	Year
12942088	CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth Nishimura, T, Fukata, Y, Kato, K, Yamaguchi, T, Matsuura, Y, Kamiguchi, H, Kaibuchi, K	Nat Cell Biol	2003