Reactome | Interaction of NUMB with L1

Interaction of NUMB with L1

Stable Identifier

R-HSA-443783

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Numb is thought to be a phosphotyrosine binding (PTB) domain containing cargo specific adaptor protein, which links specific cargo to the endocytic machinery. It associates with collapsin response mediator protein-2 (CRMP 2) with its PTB domain and alpha adaptin (a subunit of the AP 2 adaptor complex) through its tripeptide Asp-Pro-Phe (DPF) motif, and is involved in clathrin dependent endocytosis at the plasma membrane. Numb is associated with L1 under physiological conditions and functions in endocytosis of L1 in the C domain membrane of axonal growth cones.

Literature References

PubMed ID	Title	Journal	Year
12942088	CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth Matsuura, Y, Kato, K, Kaibuchi, K, Kamiguchi, H, Nishimura, T, Fukata, Y, Yamaguchi, T	Nat Cell Biol	2003