CHL1 interacts with contactin-6

Stable Identifier
R-HSA-443782
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CHL1 interacts with contactin-6
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Close homolog of L1 (CHL1), associates with Contactin-6/NB-3, a member of the F3/contactin family of neural recognition molecules, and enhances its cell surface expression. CHL1 and NB3 may engage in a cis-interaction and form a coreceptor/adhesion complex on the neuronal surface.
CHL1/NB3 clustering activates protein tyrosine phosphatase alpha (PTP alpha), which dephosphorylates and activates Fyn. Both PTP alpha and Fyn are required for proper apical dendrite orientation of deep layer pyramidal neurons.
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Output
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as an event of
Inferred From
CHL1 interacts with contactin-6 (Mus musculus)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-12)
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