Reactome | Linkage of L1 with treadmilling F-actin

Linkage of L1 with treadmilling F-actin

Stable Identifier

R-HSA-443779

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The COOH termini of all ERM proteins have sequence motifs that bind directly to F-actin. The L1 molecules on the cell surface are translocated to the C-domain by coupling with the retrograde F-actin. The force generated by linking L1 clusters with retrograde F-actin flow leads to the migration of the growth cone.

Literature References

PubMed ID	Title	Journal	Year
18478542	Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation Sakurai, T, Gil, OD, Whittard, JD, Gazdoiu, M, Joseph, T, Wu, J, Waksman, A, Benson, DL, Salton, SR, Felsenfeld, DP	J Neurosci Res	2008