Linkage of L1 with treadmilling F-actin

Stable Identifier
R-HSA-443779
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Linkage of L1 with treadmilling F-actin
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The COOH termini of all ERM proteins have sequence motifs that bind directly to F-actin. The L1 molecules on the cell surface are translocated to the C-domain by coupling with the retrograde F-actin. The force generated by linking L1 clusters with retrograde F-actin flow leads to the migration of the growth cone.
Literature References
PubMed ID Title Journal Year
18478542 Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation

Salton, SR, Gil, OD, Gazdoiu, M, Sakurai, T, Benson, DL, Joseph, T, Felsenfeld, DP, Whittard, JD, Waksman, A, Wu, J

J Neurosci Res 2008
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Orthologous Events
Linkage of L1 with treadmilling F-actin (Caenorhabditis elegans)
Linkage of L1 with treadmilling F-actin (Mus musculus)
Linkage of L1 with treadmilling F-actin (Rattus norvegicus)
Linkage of L1 with treadmilling F-actin (Xenopus tropicalis)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-12)
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