Reactome | KCNQ2 [plasma membrane]

KCNQ2 [plasma membrane]

Stable Identifier

R-HSA-443613

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium voltage-gated channel subfamily KQT member 2, KCNQ2_HUMAN

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Voltage gated Potassium channels (Homo sapiens)
    - Activation of voltage gated Potassium channels (Homo sapiens)
      - Octamer of Voltage gated K+ channels [plasma membrane] (Homo sapiens)
        
        Voltage gated potassium channel subunits Kv1-12 [plasma membrane] (Homo sapiens)
        
        Kv7 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)
        
        KCNQ2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43526 KCNQ2

Gene Names

KCNQ2

Chain

chain:1-872

Reference Genes

BioGPS Gene:3785 KCNQ2

COSMIC (genes):KCNQ2 KCNQ2

CTD Gene:3785 KCNQ2

dbSNP Gene:3785 KCNQ2

ENSEMBL:ENSG00000075043 KCNQ2

ENSEMBL_homo_sapiens_GENE:ENSG00000075043.21 KCNQ2

HGNC:6296 KCNQ2

KEGG Gene (Homo sapiens):3785 KCNQ2

Monarch:3785 KCNQ2

NCBI Gene:3785 KCNQ2

OMIM:602235 KCNQ2

UCSC:O43526 KCNQ2

Reference Transcript

Other Identifiers

11730086_a_at

11737695_a_at

11740180_x_at

11742065_a_at

16921224

16921226

205737_PM_at

205737_at

210508_PM_s_at

210508_s_at

211486_PM_s_at

211486_s_at

3785

3913819

3913820

3913822

3913823

3913824

3913825

3913826

3913827

3913828

3913829

3913830

3913831

3913832

3913833

3913839

3913840

3913841

3913842

3913843

3913847

3913857

3913858

3913859

3913860

3913869

3913870

3913875

3913876

3913877

3913879

3913888

3913889

3913890

3913891

41589_at

8067626

A_21_P0010073

A_23_P210400

A_23_P351204

A_23_P422778

A_33_P3326807

A_33_P3395823

D82346_at

GE60321

GO:0005215

GO:0005216

GO:0005249

GO:0005267

GO:0005515

GO:0005516

GO:0005886

GO:0006811

GO:0006813

GO:0007268

GO:0007399

GO:0008076

GO:0008092

GO:0016020

GO:0023052

GO:0030506

GO:0033268

GO:0034220

GO:0034702

GO:0043194

GO:0045202

GO:0048856

GO:0055085

GO:0071805

HMNXSV003016499

HMNXSV003020408

HMNXSV003024529

HMNXSV003030775

HMNXSV003031342

ILMN_1666776

ILMN_1703500

ILMN_1788663

PH_hs_0026565

PH_hs_0028724

TC20001029.hg

TC20001030.hg

TC20001031.hg

TC20001713.hg

TC20001714.hg

g1841341_3p_a_at

g1841341_3p_x_at

g4324686_3p_a_at

g4758627_3p_at

p21481

Participates

as a member of

Inferred To

KCNQ2 [plasma membrane] (Bos taurus)

KCNQ2 [plasma membrane] (Gallus gallus)

KCNQ [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_742104.1, NP_742107.1, NP_004509.2, NP_742105.1, NP_742106.1

ZINC - World Drugs

KCNQ2_HUMAN

Guide to Pharmacology - Targets

561

OpenTargets

ENSG00000075043

ZINC - FDA approved

KCNQ2_HUMAN

ZINC - Substances

KCNQ2_HUMAN

ZINC target

O43526

PRO

O43526

PDB

7CR4, 6FEG, 7CR1, 7CR3, 6FEH, 5J03, 7CR7, 7CR0, 7CR2

HPA

ENSG00000075043-KCNQ2

GeneCards

O43526

Ensembl

ENST00000626839, ENSP00000352035, ENST00000344462, ENSG00000075043, ENST00000344425, ENSP00000353668, ENSP00000486706, ENSP00000345523, ENST00000360480, ENSP00000339611, ENST00000359125

Pharos - Targets

O43526

Orphanet

16296

ZINC - Predictions - Purchasable

KCNQ2_HUMAN

HMDB Protein

HMDBP10839