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NUMB [plasma membrane]
Stable Identifier
R-HSA-443595
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Protein numb homolog, NUMB_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P42566 EPS15
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI1 by the proteasome (Homo sapiens)
NUMB binds ITCH (Homo sapiens)
NUMB [plasma membrane] (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
NUMB binds ITCH (Homo sapiens)
NUMB [plasma membrane] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
NOTCH1 associates with negative regulators NUMB and ITCH (Homo sapiens)
NUMB [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49757 NUMB
Gene Names
NUMB, C14orf41
Chain
chain:1-651
Reference Genes
BioGPS Gene:8650 NUMB
COSMIC (genes):NUMB NUMB
CTD Gene:8650 NUMB
dbSNP Gene:8650 NUMB
ENSEMBL:ENSG00000133961 NUMB
ENSEMBL_homo_sapiens_GENE:ENSG00000133961.21 NUMB
HGNC:8060 NUMB
KEGG Gene (Homo sapiens):8650 NUMB
Monarch:8650 NUMB
NCBI Gene:8650 NUMB
OMIM:603728 NUMB
UCSC:P49757 NUMB
Reference Transcript
RefSeq:NM_001320114.1 NUMB
RefSeq:NM_001005744.1 NUMB
RefSeq:NM_003744.5 NUMB
RefSeq:NM_001005745.1 NUMB
RefSeq:NM_001005743.1 NUMB
Other Identifiers
11717946_x_at
11717947_a_at
11741062_s_at
11741063_a_at
11751092_s_at
207545_PM_s_at
207545_s_at
209073_PM_s_at
209073_s_at
3571342
3571343
3571345
3571348
3571349
3571350
3571351
3571352
3571353
3571354
3571356
3571360
3571363
3571366
3571367
3571369
3571371
3571373
3571377
3571378
3571386
3571390
3571392
37693_at
7980005
8650
A_23_P88381
GE57760
GO:0005515
GO:0005737
GO:0005768
GO:0005769
GO:0005886
GO:0005905
GO:0005925
GO:0007399
GO:0007405
GO:0007409
GO:0008013
GO:0010008
GO:0016020
GO:0016192
GO:0016323
GO:0021670
GO:0021849
GO:0030136
GO:0030154
GO:0030335
GO:0030900
GO:0031410
GO:0034330
GO:0034332
GO:0043226
GO:0045177
GO:0045294
GO:0045296
GO:0048856
GO:0048870
GO:0050769
GO:0072659
GO:0098978
GO:0099149
GO:1903077
HMNXSV003014490
HMNXSV003040684
ILMN_1705114
ILMN_2331266
L40393_at
PH_hs_0026037
PH_hs_0033520
TC14001288.hg
g4102704_3p_a_at
g4505478_3p_a_at
p19339
p33770
Participates
as a protein marker of
keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)
as a component of
CRMP-2:NUMB:alpha adaptin [plasma membrane] (Homo sapiens)
NUMB:ITCH [cytosol] (Homo sapiens)
Ub-NOTCH1:NUMB:ITCH [plasma membrane] (Homo sapiens)
NOTCH1:NUMB:ITCH [plasma membrane] (Homo sapiens)
as an input of
NUMB binds ITCH (Homo sapiens)
NOTCH1 associates with negative regulators NUMB and ITCH (Homo sapiens)
Inferred To
Ghost homologue of NUMB [plasma membrane]
(Drosophila melanogaster)
NUMB [plasma membrane]
(Bos taurus)
NUMB [plasma membrane]
(Canis familiaris)
NUMB [plasma membrane]
(Gallus gallus)
NUMB [plasma membrane]
(Sus scrofa)
Numb [plasma membrane]
(Mus musculus)
Numb [plasma membrane]
(Rattus norvegicus)
numb [plasma membrane]
(Danio rerio)
numb [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001307043.1
,
NP_003735.3
,
NP_001005744.1
,
NP_001005743.1
,
NP_001005745.1
OpenTargets
ENSG00000133961
GeneCards
P49757
HPA
ENSG00000133961-NUMB
Ensembl
ENSP00000441258
,
ENST00000356296
,
ENSP00000453209
,
ENSP00000452416
,
ENSP00000451625
,
ENST00000557597
,
ENSG00000133961
,
ENSP00000348644
,
ENST00000554546
,
ENST00000554521
,
ENST00000559312
,
ENST00000555394
,
ENST00000535282
,
ENST00000555238
,
ENSP00000446001
,
ENST00000355058
,
ENST00000555738
,
ENSP00000352563
,
ENSP00000451300
,
ENST00000544991
,
ENSP00000450817
,
ENST00000560335
,
ENSP00000347169
,
ENSP00000452888
,
ENSP00000451117
,
ENST00000359560
,
ENSP00000452069
PRO
P49757
Pharos - Targets
P49757
PDB
5NJK
,
5NJJ
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.75
6
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.718
7
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.643
6
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.632
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.571
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.569
4
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.569
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.569
3
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
0.527
4
UniProt:Q10567 AP1B1
5
AP1B1 [cytoplasmic vesicle membrane]
(R-HSA-351181)
AP1B1 [Golgi membrane]
(R-HSA-350809)
AP1B1 [lysosomal membrane]
(R-HSA-432699)
AP1B1 [trans-Golgi network membrane]
(R-HSA-2130596)
AP1B1 [cytosol]
(R-HSA-167705)
0.527
4
UniProt:P61962 DCAF7
2
DCAF7 [nucleoplasm]
(R-HSA-8863312)
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
0.508
2
UniProt:Q96D71 REPS1
1
REPS1 [cytosol]
(R-HSA-8862265)
0.499
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.499
2
UniProt:P35568 IRS1
5
p-Y-IRS1 [plasma membrane]
(R-HSA-198366)
p-Y-IRS1 [cytosol]
(R-HSA-74772)
IRS1 [cytosol]
(R-HSA-74769)
IRS1 [plasma membrane]
(R-HSA-2425392)
p-6Y-IRS1 [plasma membrane]
(R-HSA-2445090)
0.488
2
UniProt:O43559 FRS3
3
p-5Y-FRS3 [plasma membrane]
(R-HSA-191475)
FRS3 [plasma membrane]
(R-HSA-191482)
p-Y-FRS3 [plasma membrane]
(R-HSA-9032427)
0.488
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.483
2
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.463
2
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