GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K

Stable Identifier
R-HSA-443402
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
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Resting platelets contain a heterotrimeric complex of GPIb-IX-V, 14-3-3-zeta and the p85 subunit of PI-3K. While GPIb-IX-V has no apparent binding sites for PI3K so the interaction with p85 is likely to be mediated by 14-3-3-zeta.
Literature References
PubMed ID Title Journal Year
10887121 Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta

Berndt, MC, Munday, AD, Mitchell, CA

Blood 2000
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Output
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Orthologous Events
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Bos taurus)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Danio rerio)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Gallus gallus)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Mus musculus)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Rattus norvegicus)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Sus scrofa)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Xenopus tropicalis)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-10-06)
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