Reactome | SCN2A [plasma membrane]

SCN2A [plasma membrane]

Stable Identifier

R-HSA-443377

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sodium channel protein type 2 subunit alpha, SCN2A_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - Interaction between L1 and Ankyrins (Homo sapiens)
        
        Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs [plasma membrane] (Homo sapiens)
        
        SCN2A [plasma membrane] (Homo sapiens)
        
        NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs [plasma membrane] (Homo sapiens)
        
        SCN2A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99250 SCN2A

Gene Names

SCN2A, NAC2, SCN2A1, SCN2A2

Chain

chain:1-2005

Reference Genes

BioGPS Gene:6326 SCN2A

COSMIC (genes):SCN2A SCN2A

CTD Gene:6326 SCN2A

dbSNP Gene:6326 SCN2A

ENSEMBL:ENSG00000136531 SCN2A

HGNC:10588 SCN2A

KEGG Gene (Homo sapiens):6326 SCN2A

Monarch:6326 SCN2A

NCBI Gene:6326 SCN2A

OMIM:182390 SCN2A

UCSC:Q99250 SCN2A

Reference Transcript

Other Identifiers

0003170541

0100870471

11735263_s_at

11739999_a_at

16887062

206381_at

229057_at

2513472

2513474

2513475

2513476

2513479

2513483

2513484

2513485

2513486

2513487

2513488

2513490

2513491

2513492

2513493

2513494

2513495

2513496

2513500

2513501

2513505

2513506

2513507

2513508

2513510

2513511

2513512

2513513

2513515

2513516

2513517

2513519

2513521

2513522

2513524

2513525

2513526

2513527

2513549

2585331

2585366

2585444

2585446

36725_at

48890_at

6326

64605_at

8046020

A_14_P110683

A_14_P202302

A_23_P51019

GE56734

GE58155

GE834169

GO:0001518

GO:0003674

GO:0005216

GO:0005244

GO:0005248

GO:0005261

GO:0005272

GO:0005515

GO:0005575

GO:0005886

GO:0005887

GO:0006810

GO:0006811

GO:0006814

GO:0006950

GO:0007165

GO:0007399

GO:0007613

GO:0008150

GO:0008219

GO:0008627

GO:0014704

GO:0016020

GO:0016021

GO:0019228

GO:0022857

GO:0030315

GO:0030424

GO:0031226

GO:0032991

GO:0033268

GO:0033270

GO:0034706

GO:0034765

GO:0035725

GO:0042552

GO:0048856

GO:0050877

GO:0051402

GO:0055085

GO:0071456

GO:0086010

Hs.93485.0.S1_3p_at

ILMN_1732782

ILMN_2271762

ILMN_2366915

M94055_at

PH_hs_0025442

TC02000985.hg

TC02003665.hg

g10337596_3p_at

Participant Of

hasCandidate

SCNAs [plasma membrane]

Inferred To

fam161a [plasma membrane] (Xenopus tropicalis)

scn1lab [plasma membrane] (Danio rerio)

Homologues of SCN2A [plasma membrane] (Danio rerio)

Homologues of SCN2A [plasma membrane] (Xenopus tropicalis)

scn3a [plasma membrane] (Xenopus tropicalis)

SCN2A [plasma membrane] (Gallus gallus)

SCN2A [plasma membrane] (Sus scrofa)

Scn2a [plasma membrane] (Mus musculus)

Scn2a [plasma membrane] (Rattus norvegicus)

cdknx [plasma membrane] (Xenopus tropicalis)

scn1laa [plasma membrane] (Danio rerio)

Cross References

RefSeq

XP_016860144.1, XP_016860146.1, NP_001035233.1, NP_066287.2, NP_001035232.1, XP_016860145.1, XP_005246810.1

ZINC - World Drugs

SCN2A_HUMAN

OpenTargets

ENSG00000136531

ZINC - FDA approved

SCN2A_HUMAN

ZINC - Substances

SCN2A_HUMAN

ZINC target

Q99250

ZINC - Biogenic

SCN2A_HUMAN

PRO

Q99250

PDB

4RLY, 4JPZ, 6BUT, 2KAV, 6J8E

GeneCards

Q99250

HPA

ENSG00000136531-SCN2A

Ensembl

ENSP00000490866, ENST00000283256, ENSP00000283256, ENSP00000364586, ENST00000636071, ENST00000375437, ENSP00000490107, ENSG00000136531, ENST00000631182, ENST00000637266, ENSP00000486885

ZINC - Predictions - Purchasable

SCN2A_HUMAN

Orphanet

15252

HMDB Protein

HMDBP09080