Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
SCN2A [plasma membrane]
Stable Identifier
R-HSA-443377
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sodium channel protein type 2 subunit alpha, SCN2A_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Interaction between L1 and Ankyrins (Homo sapiens)
Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs [plasma membrane] (Homo sapiens)
SCN2A [plasma membrane] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs [plasma membrane] (Homo sapiens)
SCN2A [plasma membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 0 - rapid depolarisation (Homo sapiens)
SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Homo sapiens)
SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs [plasma membrane] (Homo sapiens)
SCN2A [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)
SCN2A [plasma membrane] (Homo sapiens)
SCN2A:SCN1B,2B,4B [plasma membrane] (Homo sapiens)
SCN2A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99250 SCN2A
Gene Names
SCN2A, NAC2, SCN2A1, SCN2A2
Chain
chain:1-2005
Reference Genes
BioGPS Gene:6326 SCN2A
COSMIC (genes):SCN2A SCN2A
CTD Gene:6326 SCN2A
dbSNP Gene:6326 SCN2A
ENSEMBL:ENSG00000136531.19 SCN2A
HGNC:10588 SCN2A
KEGG Gene (Homo sapiens):6326 SCN2A
Monarch:6326 SCN2A
NCBI Gene:6326 SCN2A
OMIM:182390 SCN2A
UCSC:Q99250 SCN2A
Reference Transcript
RefSeq:NM_001040142.1 SCN2A
RefSeq:NM_021007.2 SCN2A
RefSeq:NM_001040143.1 SCN2A
RefSeq:XM_017004655.1 SCN2A
RefSeq:XM_005246753.3 SCN2A
RefSeq:XM_017004657.1 SCN2A
RefSeq:XM_017004656.1 SCN2A
Other Identifiers
0003170541
0100870471
11735263_s_at
11739999_a_at
16887062
206381_PM_at
206381_at
229057_PM_at
229057_at
2513472
2513474
2513475
2513476
2513479
2513483
2513484
2513485
2513486
2513487
2513488
2513490
2513491
2513492
2513493
2513494
2513495
2513496
2513500
2513501
2513505
2513506
2513507
2513508
2513510
2513511
2513512
2513513
2513515
2513516
2513517
2513519
2513521
2513522
2513524
2513525
2513526
2513527
2513549
2585331
2585366
2585444
2585446
36725_at
48890_at
6326
64605_at
8046020
A_14_P110683
A_14_P202302
A_23_P51019
GE56734
GE58155
GE834169
GO:0001518
GO:0005215
GO:0005216
GO:0005244
GO:0005248
GO:0005261
GO:0005272
GO:0005515
GO:0005886
GO:0005887
GO:0006811
GO:0006814
GO:0007399
GO:0007613
GO:0008627
GO:0012501
GO:0014704
GO:0016020
GO:0016021
GO:0019228
GO:0023052
GO:0030315
GO:0030424
GO:0031226
GO:0032991
GO:0033268
GO:0033270
GO:0034706
GO:0034765
GO:0035725
GO:0042552
GO:0048856
GO:0050877
GO:0051402
GO:0055085
GO:0071456
GO:0086010
GO:0098978
GO:0099056
HMNXSV003053729
Hs.93485.0.S1_3p_at
ILMN_1732782
ILMN_2271762
ILMN_2366915
M94055_at
PH_hs_0025442
TC02000985.hg
TC02003665.hg
g10337596_3p_at
Participates
as a component of
SCN2A:SCN1B,2B,4B [plasma membrane] (Homo sapiens)
as a candidate of
SCNAs [plasma membrane] (Homo sapiens)
Inferred To
scn2a [plasma membrane]
(Xenopus tropicalis)
SCN3A [plasma membrane]
(Bos taurus)
Cross References
RefSeq
NP_001035233.1
,
XP_005246810.1
,
NP_001035232.1
,
XP_016860144.1
,
XP_016860146.1
,
NP_066287.2
,
XP_016860145.1
ZINC - World Drugs
SCN2A_HUMAN
Guide to Pharmacology - Targets
579
OpenTargets
ENSG00000136531
ZINC - FDA approved
SCN2A_HUMAN
ZINC - Substances
SCN2A_HUMAN
ZINC - Biogenic
SCN2A_HUMAN
ZINC target
Q99250
PRO
Q99250
PDB
4JPZ
,
6BUT
,
4RLY
,
6J8E
,
2KAV
GeneCards
Q99250
HPA
ENSG00000136531-SCN2A
Ensembl
ENSP00000283256
,
ENSG00000136531
,
ENSP00000490107
,
ENST00000636071
,
ENSP00000364586
,
ENSP00000486885
,
ENST00000631182
,
ENSP00000490866
,
ENST00000375437
,
ENST00000637266
,
ENST00000283256
Pharos - Targets
Q99250
Orphanet
15252
ZINC - Predictions - Purchasable
SCN2A_HUMAN
HMDB Protein
HMDBP09080
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text