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SCN2A [plasma membrane]
Stable Identifier
R-HSA-443377
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sodium channel protein type 2 subunit alpha, SCN2A_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Interaction between L1 and Ankyrins (Homo sapiens)
Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs [plasma membrane] (Homo sapiens)
SCN2A [plasma membrane] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs [plasma membrane] (Homo sapiens)
SCN2A [plasma membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 0 - rapid depolarisation (Homo sapiens)
SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Homo sapiens)
SCNAs:SCNBs [plasma membrane] (Homo sapiens)
SCNAs [plasma membrane] (Homo sapiens)
SCN2A [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)
SCN2A [plasma membrane] (Homo sapiens)
SCN2A:SCN1B,2B,4B [plasma membrane] (Homo sapiens)
SCN2A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99250 SCN2A
Gene Names
SCN2A, NAC2, SCN2A1, SCN2A2, SCN2A2
Chain
chain:1-2005
Reference Genes
BioGPS Gene:6326 SCN2A
COSMIC (genes):SCN2A SCN2A
CTD Gene:6326 SCN2A
dbSNP Gene:6326 SCN2A
ENSEMBL:ENSG00000136531 SCN2A
HGNC:10588 SCN2A
KEGG:hsa:6326 SCN2A
Monarch:6326 SCN2A
NCBI Gene:6326 SCN2A
OMIM:182390 SCN2A
UCSC:Q99250 SCN2A
Reference Transcript
RefSeq:XM_017004655.1 SCN2A
RefSeq:NM_001040143.2 SCN2A
RefSeq:XM_005246753.3 SCN2A
RefSeq:NM_001040142.2 SCN2A
RefSeq:NM_001371246.1 SCN2A
RefSeq:XM_017004657.1 SCN2A
RefSeq:NM_021007.3 SCN2A
RefSeq:XM_017004656.1 SCN2A
RefSeq:NM_001371247.1 SCN2A
Other Identifiers
11735263_s_at
11739999_a_at
16887062
206381_PM_at
206381_at
229057_PM_at
229057_at
2513468
2513472
2513474
2513475
2513476
2513477
2513478
2513479
2513483
2513484
2513485
2513486
2513487
2513488
2513489
2513490
2513491
2513492
2513493
2513494
2513495
2513496
2513500
2513501
2513502
2513503
2513504
2513505
2513506
2513507
2513508
2513510
2513511
2513512
2513513
2513514
2513515
2513516
2513517
2513519
2513520
2513521
2513522
2513524
2513525
2513526
2513527
2513529
2513530
2513531
2513532
2513533
2513534
2513538
2513540
2513549
2585331
2585366
2585444
2585446
36725_at
48890_at
6326
64605_at
8046020
A_14_P110683
A_14_P202302
A_23_P51019
GE56734
GE58155
GE834169
GO:0001518
GO:0005215
GO:0005216
GO:0005248
GO:0005261
GO:0005272
GO:0005515
GO:0005516
GO:0005886
GO:0006811
GO:0006814
GO:0007399
GO:0007613
GO:0008627
GO:0012501
GO:0016020
GO:0019228
GO:0030424
GO:0033268
GO:0034220
GO:0034702
GO:0035725
GO:0042391
GO:0042552
GO:0048856
GO:0050877
GO:0051402
GO:0055085
GO:0071456
GO:0086002
GO:0098655
HMNXSV003048288
HMNXSV003053729
Hs.93485.0.S1_3p_at
ILMN_1732782
ILMN_2271762
ILMN_2366915
M94055_at
PH_hs_0025442
TC02000985.hg
TC02003665.hg
g10337596_3p_at
Participates
as a component of
SCN2A:SCN1B,2B,4B [plasma membrane] (Homo sapiens)
as a candidate of
SCNAs [plasma membrane] (Homo sapiens)
Inferred To
SCN1A [plasma membrane]
(Bos taurus)
Cross References
RefSeq
NP_001035232.1
,
NP_001035233.1
,
XP_016860144.1
,
XP_016860145.1
,
NP_001358176.1
,
NP_066287.2
,
NP_001358175.1
,
XP_005246810.1
,
XP_016860146.1
ZINC - World Drugs
SCN2A_HUMAN
Guide to Pharmacology - Targets
579
OpenTargets
ENSG00000136531
ENSEMBL
ENSP00000490866
,
ENSP00000490107
,
ENSP00000486885
,
ENST00000283256
,
ENSG00000136531
,
ENST00000375437
,
ENST00000636071
,
ENST00000631182
,
ENSP00000283256
,
ENST00000637266
,
ENSP00000364586
ZINC - FDA approved
SCN2A_HUMAN
ZINC - Substances
SCN2A_HUMAN
ZINC - Biogenic
SCN2A_HUMAN
ZINC target
Q99250
PRO
Q99250
GlyGen
Q99250
PDB
4JPZ
,
2KAV
,
4RLY
,
6J8E
,
6BUT
HPA
ENSG00000136531-SCN2A
GeneCards
SCN2A
Pharos - Targets
Q99250
Orphanet
SCN2A
ZINC - Predictions - Purchasable
SCN2A_HUMAN
HMDB Protein
HMDBP09080
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