PAK phosphorylates cortactin

Stable Identifier
R-HSA-442832
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PAK phosphorylates cortactin
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PAKs can associate with cortactin (CTTN), a cortical actin binding protein, irrespective of the activation status of PAKs. Once activated, PAKs phosphorylate cortactin, predominantly at Ser113 in the first actin-binding repeat. Cortactin phosphorylation modulates its interaction with actin and actin cytoskeleton regulators and is involved in cell motility (Weed et al. 1998, Vidal et al. 2002, Webb et al. 2006, Grassart et al. 2010, Moshfegh et al. 2014).
Literature References
PubMed ID Title Journal Year
24859002 A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly

Moshfegh, Y, Bravo-Cordero, JJ, Miskolci, V, Condeelis, J, Hodgson, L

Nat. Cell Biol. 2014
20444238 Pak1 phosphorylation enhances cortactin-N-WASP interaction in clathrin-caveolin-independent endocytosis

Grassart, A, Meas-Yedid, V, Dufour, A, Olivo-Marin, JC, Dautry-Varsat, A, Sauvonnet, N

Traffic 2010
12453877 Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin

Vidal, C, Geny, B, Melle, J, Jandrot-Perrus, M, Fontenay-Roupie, M

Blood 2002
9683637 Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1

Weed, SA, Du, Y, Parsons, JT

J Cell Sci 1998
16854367 Phosphorylation of cortactin by p21-activated kinase

Webb, BA, Zhou, S, Eves, R, Shen, L, Jia, L, Mak, AS

Arch Biochem Biophys 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S,T-PAK1,2,3 [cytosol]

Physical Entity
p-S,T-PAK1,2,3 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Pak3 phosphorylates Cttn (Mus musculus)
Authored
Orlic-Milacic, M  (2015-02-02)
Rivero Crespo, F  (2014-12-26)
Created
Jupe, S  (2009-09-29)
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