Activation of RasGRF

Stable Identifier
Reaction [binding]
Homo sapiens
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After Ca2+ influx through the activated NMDA receptors, RASGRF1 homooligomers and heterooligomers with RASGRF2 are activated by binding to the Ca2+:Calmodulin complex (CALM1:4xCa2+) and by associating with the GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors through direct interaction between GluN2B and RASGRF1 (Anborgh et al. 1999, Krapivinsky et al. 2003).

Literature References
PubMed ID Title Journal Year
14622581 The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1

Krapivinsky, G, Krapivinsky, L, Manasian, Y, Ivanov, A, Tyzio, R, Pellegrino, C, Ben-Ari, Y, Clapham, DE, Medina, I

Neuron 2003
10373510 Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf

Anborgh, PH, Qian, X, Papageorge, AG, Vass, WC, DeClue, JE, Lowy, DR

Mol Cell Biol 1999
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