Activation of RasGRF

Stable Identifier
R-HSA-442760
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Activation of RasGRF
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After Ca2+ influx through the activated NMDA receptors, RASGRF1 homooligomers and heterooligomers with RASGRF2 are activated by binding to the Ca2+:Calmodulin complex (CALM1:4xCa2+) and by associating with the GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors through direct interaction between GluN2B and RASGRF1 (Anborgh et al. 1999, Krapivinsky et al. 2003).
Literature References
PubMed ID Title Journal Year
10373510 Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf

Qian, X, Papageorge, AG, Vass, WC, Lowy, DR, DeClue, JE, Anborgh, PH

Mol Cell Biol 1999
14622581 The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1

Tyzio, R, Krapivinsky, G, Medina, I, Manasian, Y, Clapham, DE, Ivanov, A, Krapivinsky, L, Pellegrino, C, Ben-Ari, Y

Neuron 2003
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Inferred From
Rasgrf1 oligomers bind GluN1:GluN2B (Grin1:Grin2b) di-heterotetramers (Rattus norvegicus)
Authored
Mahajan, SS  (2009-10-29)
Reviewed
Tukey, D  (2009-11-18)
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Mahajan, SS  (2009-09-29)
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