Reactome | RASGRF1 [plasma membrane]

RASGRF1 [plasma membrane]

Stable Identifier

R-HSA-442723

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ras-specific guanine nucleotide-releasing factor 1, RGRF1_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
        
        Activation of RasGRF (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        RASGRF1 oligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 homooligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 [plasma membrane] (Homo sapiens)
        
        RASGRF1:RASGRF2 heterooligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 [plasma membrane] (Homo sapiens)
        
        RASGRF1 oligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 homooligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 [plasma membrane] (Homo sapiens)
        
        RASGRF1:RASGRF2 heterooligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 [plasma membrane] (Homo sapiens)
        
        NMDA-activated RASGRF1 activates RAS (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        RASGRF1 oligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 homooligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 [plasma membrane] (Homo sapiens)
        
        RASGRF1:RASGRF2 heterooligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        RASGRF1 oligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 homooligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 [plasma membrane] (Homo sapiens)
        
        RASGRF1:RASGRF2 heterooligomer [plasma membrane] (Homo sapiens)
        
        RASGRF1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13972 RASGRF1

Gene Names

RASGRF1, CDC25, GNRP, GRF1

Chain

chain:1-1273

Reference Genes

BioGPS Gene:5923 RASGRF1

COSMIC (genes):RASGRF1 RASGRF1

CTD Gene:5923 RASGRF1

dbSNP Gene:5923 RASGRF1

ENSEMBL:ENSG00000058335 RASGRF1

ENSEMBL:ENSG00000058335.16 RASGRF1

HGNC:9875 RASGRF1

KEGG Gene (Homo sapiens):5923 RASGRF1

Monarch:5923 RASGRF1

NCBI Gene:5923 RASGRF1

OMIM:606600 RASGRF1

UCSC:Q13972 RASGRF1

Reference Transcript

Other Identifiers

11730400_a_at

11730401_a_at

11749532_a_at

11751980_a_at

16812274

1921_at

1922_g_at

210550_PM_s_at

210550_s_at

214905_PM_at

214905_at

31925_s_at

31949_at

3634853

3634854

3634855

3634858

3634860

3634861

3634868

3634873

3634878

3634880

3634883

3634885

3634887

3634888

3634889

3634891

3634892

3634893

3634894

3634896

3634897

3634899

3634900

3634901

3634902

3634903

3634906

3634907

3634908

3634909

3634910

3634912

3634914

3634916

3634928

3634929

3634933

39217_at

5923

7990774

A_23_P3371

A_23_P3379

GE481155

GE81205

GO:0005085

GO:0005515

GO:0005829

GO:0005886

GO:0007165

GO:0007264

GO:0007265

GO:0007616

GO:0023052

GO:0030154

GO:0030426

GO:0031175

GO:0034976

GO:0035020

GO:0035254

GO:0035556

GO:0043005

GO:0043547

GO:0044342

GO:0046578

GO:0046579

GO:0048167

GO:0048168

GO:0048856

GO:0050877

GO:0055085

GO:0090630

GO:0098772

GO:2000310

HMNXSV003004763

HMNXSV003015492

Hs.221811.0.S1_3p_at

ILMN_1748083

ILMN_1779386

L26584_s_at

PH_hs_0032210

TC15001714.hg

TC15002647.hg

g433719_3p_a_at

Participates

as a component of

Inferred To

RASGRF1 [plasma membrane] (Bos taurus)

RASGRF1 [plasma membrane] (Canis familiaris)

RASGRF1 [plasma membrane] (Gallus gallus)

RASGRF1 [plasma membrane] (Sus scrofa)

Rasgrf1 [plasma membrane] (Mus musculus)

Rasgrf1 [plasma membrane] (Rattus norvegicus)

si:ch211-234p18.3 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_002882.3, NP_722522.1

OpenTargets

ENSG00000058335

GeneCards

Q13972

HPA

ENSG00000058335-RASGRF1

Ensembl

ENSP00000452781, ENSP00000405963, ENSG00000058335, ENSP00000378228, ENST00000558480, ENST00000419573, ENST00000394745

PRO

Q13972

Pharos - Targets

Q13972

HMDB Protein

HMDBP08546