hZIP5 mediates zinc uptake by cells

Stable Identifier
R-HSA-442405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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hZIP5 mediates zinc uptake by cells
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The human gene SLC39A5 encodes the zinc transporter hZIP5 (Wang F et al, 2004). Highest expressions are seen in liver, kidney, pancreas and throughout the small intestine and colon with little expression detected in other tissues. hZIP5 is localized to the basolateral membrane of cells in these tissues. The functionality of ZIP5 as a zinc transporter was determined using mouse protein (mZIP5) (Wang F et al, 2004).
Literature References
PubMed ID Title Journal Year
15322118 The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells

Petris, MJ, Kim, BE, Wang, F, Eide, DJ

J Biol Chem 2004
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as an event of
Catalyst Activity

zinc ion transmembrane transporter activity of SLC39A5 [plasma membrane]

Physical Entity
SLC39A5 [plasma membrane] (Homo sapiens)
Activity
zinc ion transmembrane transporter activity (GO:0005385)
Inferred From
mZIP5 mediates zinc uptake by cells (Mus musculus)
Cross References
Rhea
Authored
Jassal, B  (2009-09-25)
Reviewed
He, L  (2009-11-12)
Created
Jassal, B  (2009-09-25)
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