Reactome | SLC39A2 [plasma membrane]

SLC39A2 [plasma membrane]

Stable Identifier

R-HSA-442395

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

hZIP2, Zinc transporter ZIP2, S39A2_HUMAN

Locations in the PathwayBrowser

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc influx into cells by the SLC39 gene family (Homo sapiens)
        
        SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Homo sapiens)
        
        SLC39A1-4 [plasma membrane] (Homo sapiens)
        
        SLC39A2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NP94 SLC39A2

Gene Names

SLC39A2, ZIP2

Chain

chain:1-309

Reference Genes

BioGPS Gene:29986 SLC39A2

COSMIC (genes):SLC39A2 SLC39A2

CTD Gene:29986 SLC39A2

dbSNP Gene:29986 SLC39A2

ENSEMBL:ENSG00000165794 SLC39A2

HGNC:17127 SLC39A2

KEGG:hsa:29986 SLC39A2

Monarch:29986 SLC39A2

NCBI Gene:29986 SLC39A2

OMIM:612166 SLC39A2

UCSC:Q9NP94 SLC39A2

Reference Transcript

Other Identifiers

11728506_at

16781648

220413_PM_at

220413_at

29986

3527786

3527787

3527789

3527790

3527791

3527792

3527793

3527794

59560_at

7973135

A_14_P136980

A_14_P200371

A_23_P128855

GE81941

GO:0005215

GO:0005385

GO:0005515

GO:0005886

GO:0006829

GO:0016020

GO:0030001

GO:0030154

GO:0030216

GO:0031410

GO:0036464

GO:0043226

GO:0046873

GO:0055085

GO:0070574

GO:0071577

HMNXSV003043228

ILMN_1810025

PH_hs_0010487

TC14000075.hg

TC14001582.hg

g7657698_3p_at

Participates

as a member of

SLC39A1-4 [plasma membrane] (Homo sapiens)

Inferred To

Zip42C.2 [plasma membrane] (Drosophila melanogaster)

Zip89B [plasma membrane] (Drosophila melanogaster)

ATX2 [plasma membrane] (Saccharomyces cerevisiae)

Homologues of SLC39A2 [plasma membrane] (Dictyostelium discoideum)

Homologues of SLC39A2 [plasma membrane] (Drosophila melanogaster)

Homologues of SLC39A2 [plasma membrane] (Plasmodium falciparum)

slc39a2 [plasma membrane] (Xenopus tropicalis)

Zip42C.1 [plasma membrane] (Drosophila melanogaster)

zntD [plasma membrane] (Dictyostelium discoideum)

SLC39A2 [plasma membrane] (Bos taurus)

SLC39A2 [plasma membrane] (Canis familiaris)

SLC39A2 [plasma membrane] (Mus musculus)

SLC39A2 [plasma membrane] (Plasmodium falciparum)

SLC39A2 [plasma membrane] (Sus scrofa)

Slc39a2 [plasma membrane] (Rattus norvegicus)

zntA [plasma membrane] (Dictyostelium discoideum)

Zip88E [plasma membrane] (Drosophila melanogaster)

ZIP1 [plasma membrane] (Plasmodium falciparum)

zipt-1 [plasma membrane] (Caenorhabditis elegans)

slc39a1 [plasma membrane] (Danio rerio)

Cross References

Guide to Pharmacology - Targets

1181

ENSEMBL

ENST00000298681, ENSP00000452568, ENST00000554422, ENSP00000298681

OpenTargets

ENSG00000165794

HPA

ENSG00000165794-SLC39A2

PRO

Q9NP94

Pharos - Targets

Q9NP94

HMDB Protein

HMDBP11935

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75084 FZD7	1	FZD7 [plasma membrane] (R-HSA-517394)	0.556	3
UniProt:P34981 TRHR	1	TRHR [plasma membrane] (R-HSA-444556)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:P25025 CXCR2	2	CXCR2 [plasma membrane] (R-HSA-373796) CXCR2 [secretory granule membrane] (R-HSA-6804771)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:P21964 COMT	2	COMT [cytosol] (R-HSA-175974) COMT [plasma membrane] (R-HSA-379386)	0.556	3

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