ZIP7 mediates zinc efflux from the endoplasmic reticulum

Stable Identifier
R-HSA-442393
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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ZIP7 mediates zinc efflux from the endoplasmic reticulum
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The human gene SLC39A7 encodes the zinc transporter ZIP7 (HKE4, Histidine-rich membrane protein Ke4). It is expressed in many tissues but especially in liver, kidney and the hormonal tissues apart from brain. Unlike the other members of the LZT subfamily, ZIP7 is localized to intracellular membranes of the ER rather than the plasma membrane and mediates zinc efflux into the cytoplasm (Taylor KM et al, 2004).
Literature References
PubMed ID Title Journal Year
14525538 Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters

Taylor, KM, Morgan, HE, Johnson, A, Nicholson, RI

Biochem J 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

zinc ion transmembrane transporter activity of SLC39A7 [endoplasmic reticulum membrane]

Physical Entity
SLC39A7 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
zinc ion transmembrane transporter activity (GO:0005385)
Orthologous Events
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Bos taurus)
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Caenorhabditis elegans)
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Canis familiaris)
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Danio rerio)
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Drosophila melanogaster)
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Mus musculus)
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Rattus norvegicus)
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Saccharomyces cerevisiae)
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Schizosaccharomyces pombe)
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Sus scrofa)
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2009-09-25)
Reviewed
He, L  (2009-11-12)
Created
Jassal, B  (2009-09-25)
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