hZIP10 mediates zinc influx into cells

Stable Identifier
R-HSA-442345
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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hZIP10 mediates zinc influx into cells
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The human gene SLC39A10 encodes the zinc transporter hZIP10. It is thought to be involved in the invasive behaviour of breast cancer cells where depletion of hZIP10 and intracellular zinc levels inhibit the migratory effects these cells (Kagara N et al, 2007). Functional characterization of this transporter was elucidated in the rat orthologue rZip10.

Literature References
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Input
Output
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as an event of
Catalyst Activity

zinc ion transmembrane transporter activity of SLC39A10 [plasma membrane]

Physical Entity
SLC39A10 [plasma membrane] (Homo sapiens)
Activity
zinc ion transmembrane transporter activity (GO:0005385)
Inferred From
rZip10 mediates zinc influx into cells (Rattus norvegicus)
Cross References
Rhea
Authored
Jassal, B  (2009-09-25)
Reviewed
He, L  (2009-11-12)
Created
Jassal, B  (2009-09-25)
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