Reactome | SLC39A6 [plasma membrane]

SLC39A6 [plasma membrane]

Stable Identifier

R-HSA-442332

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ZIP6, LIV-1, Zinc transporter ZIP6, S39A6_HUMAN

Locations in the PathwayBrowser

Expand all

Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc influx into cells by the SLC39 gene family (Homo sapiens)
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Homo sapiens)
        
        ZIP6/ZIP14 [plasma membrane] (Homo sapiens)
        
        SLC39A6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13433 SLC39A6

Gene Names

SLC39A6, LIV1, ZIP6

Chain

signal peptide:1-28, chain:29-755

Reference Genes

BioGPS Gene:25800 SLC39A6

COSMIC (genes):SLC39A6 SLC39A6

CTD Gene:25800 SLC39A6

dbSNP Gene:25800 SLC39A6

ENSEMBL:ENSG00000141424.13 SLC39A6

HGNC:18607 SLC39A6

KEGG Gene (Homo sapiens):25800 SLC39A6

Monarch:25800 SLC39A6

NCBI Gene:25800 SLC39A6

OMIM:608731 SLC39A6

UCSC:Q13433 SLC39A6

Reference Transcript

Other Identifiers

0005900170

11735415_a_at

11749546_a_at

11757587_s_at

1555460_3p_a_at

1555460_PM_a_at

1555460_a_at

1556551_PM_s_at

1556551_s_at

16854727

1798_at

202088_PM_at

202088_at

202089_PM_s_at

202089_s_at

25800

3804200

3804201

3804202

3804203

3804204

3804205

3804206

3804207

3804208

3804209

3804210

3804211

3804212

3804213

3804214

3804217

3804218

3804219

3804221

3804222

3804223

3804226

3804227

3804228

3804229

3804230

3804231

8022927

A_23_P50167

A_24_P156049

GE59141

GO:0005215

GO:0005385

GO:0005515

GO:0005622

GO:0005737

GO:0005783

GO:0005886

GO:0005887

GO:0006811

GO:0006829

GO:0006882

GO:0009986

GO:0016020

GO:0016021

GO:0030001

GO:0031258

GO:0043226

GO:0046873

GO:0055065

GO:0055085

GO:0071577

GO:0071578

HMNXSV003036576

HMNXSV003053691

Hs.79136.0.S2_3p_at

Hs2.399943.1.S1_3p_s_at

Hs2.79136.2.S1_3p_at

Hs2.79136.2.S1_3p_s_at

ILMN_1750394

ILMN_2143566

PH_hs_0004573

TC18000458.hg

U41060_at

g12751474_3p_a_at

Participates

as a member of

ZIP6/ZIP14 [plasma membrane] (Homo sapiens)

Inferred To

Homologues of SLC39A6 [plasma membrane] (Drosophila melanogaster)

Zip71B [plasma membrane] (Drosophila melanogaster)

SLC39A6 [plasma membrane] (Bos taurus)

SLC39A6 [plasma membrane] (Canis familiaris)

SLC39A6 [plasma membrane] (Danio rerio)

SLC39A6 [plasma membrane] (Gallus gallus)

SLC39A6 [plasma membrane] (Sus scrofa)

Slc39a6 [plasma membrane] (Mus musculus)

Slc39a6 [plasma membrane] (Rattus norvegicus)

foi [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

XP_011524202.1, NP_036451.3, XP_011524203.1, NP_001092876.1

Guide to Pharmacology - Targets

1185

OpenTargets

ENSG00000141424

HPA

ENSG00000141424-SLC39A6

GeneCards

Q13433

Ensembl

ENSG00000141424, ENST00000440549, ENSP00000465915, ENST00000590986, ENSP00000401139, ENSP00000269187, ENST00000269187

PRO

Q13433

Pharos - Targets

Q13433

HMDB Protein

HMDBP11939