ZIP6 and ZIP14 mediate zinc influx into cells

Stable Identifier
Reaction [transition]
Homo sapiens
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The human gene SLC39A6 encodes the zinc transporter ZIP6 (LIV-1). The gene is oestrogen-regulated and has been implicated in metastatic breast cancer. ZIP6 mediates the transport of zinc into cells, is localized to the plasma membrane and is expressed mainly in hormonal tissues such as breast, prostate and brain (Taylor KM et al, 2003).

The human gene SLC39A14 encodes the zinc transporter ZIP14. This protein is ubiquitously expressed with higher expression seen in heart, liver and pancreas. ZIP14 is localized to the plasma membrane and mediates zinc influx into cells (Taylor KM et al, 2005).

Literature References
PubMed ID Title Journal Year
12839489 Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters

Morgan, HE, Hadley, LJ, Taylor, KM, Nicholson, RI, Johnson, A

Biochem J 2003
15642354 Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14

Morgan, HE, Taylor, KM, Nicholson, RI, Johnson, A

FEBS Lett 2005
Catalyst Activity

zinc ion transmembrane transporter activity of ZIP6/ZIP14 [plasma membrane]

Orthologous Events
Cross References
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