Reactome | ZIP6 and ZIP14 mediate zinc influx into cells

ZIP6 and ZIP14 mediate zinc influx into cells

Stable Identifier

R-HSA-442317

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc influx into cells by the SLC39 gene family (Homo sapiens)
        
        ZIP6 and ZIP14 mediate zinc influx into cells (Homo sapiens)

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ZIP6 and ZIP14 mediate zinc influx into cells

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The human gene SLC39A6 encodes the zinc transporter ZIP6 (LIV-1). The gene is oestrogen-regulated and has been implicated in metastatic breast cancer. ZIP6 mediates the transport of zinc into cells, is localized to the plasma membrane and is expressed mainly in hormonal tissues such as breast, prostate and brain (Taylor KM et al, 2003).

The human gene SLC39A14 encodes the zinc transporter ZIP14. This protein is ubiquitously expressed with higher expression seen in heart, liver and pancreas. ZIP14 is localized to the plasma membrane and mediates zinc influx into cells (Taylor KM et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
12839489	Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters Morgan, HE, Hadley, LJ, Taylor, KM, Nicholson, RI, Johnson, A	Biochem J	2003
15642354	Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14 Morgan, HE, Taylor, KM, Nicholson, RI, Johnson, A	FEBS Lett	2005