Reactome | VAV3 is a GEF for Rho/Rac family kinases

VAV3 is a GEF for Rho/Rac family kinases

Stable Identifier

R-HSA-442314

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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VAV3 is a GEF for Rho/Rac family kinases

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Vav3 is a guanine nucleotide exchange factors (GEF) for RhoA, RhoB and to a lesser extent Rac1.

Literature References

PubMed ID	Title	Journal	Year
8990121	Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product Ostrom, AA, Bustelo, XR, Gutkind, JS, Crespo, P, Schuebel, KE	Nature	1997
18589439	Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1 Kuhn, P, Tainer, JA, Streiff, M, Zhang, H, Widmer, H, Hura, GL, Chrencik, JE, Perry, JJ, Bokoch, GM, Brooun, A, Ramage, P, Foster, SA, Weckbecker, G, Mathews, II	J Mol Biol	2008