VAV3 is a GEF for Rho/Rac family kinases

Stable Identifier
R-HSA-442314
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Vav3 is a guanine nucleotide exchange factors (GEF) for RhoA, RhoB and to a lesser extent Rac1.

Literature References
PubMed ID Title Journal Year
18589439 Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1

Chrencik, JE, Brooun, A, Zhang, H, Mathews, II, Hura, GL, Foster, SA, Perry, JJ, Streiff, M, Ramage, P, Widmer, H, Bokoch, GM, Tainer, JA, Weckbecker, G, Kuhn, P

J Mol Biol 2008
8990121 Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Crespo, P, Schuebel, KE, Ostrom, AA, Gutkind, JS, Bustelo, XR

Nature 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of p-Y173-VAV3 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created