Reactome | VAV3 is a GEF for Rho/Rac family kinases

VAV3 is a GEF for Rho/Rac family kinases

Stable Identifier

R-HSA-442314

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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VAV3 is a GEF for Rho/Rac family kinases

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Vav3 is a guanine nucleotide exchange factors (GEF) for RhoA, RhoB and to a lesser extent Rac1.

Literature References

PubMed ID	Title	Journal	Year
8990121	Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product Crespo, P, Schuebel, KE, Ostrom, AA, Gutkind, JS, Bustelo, XR	Nature	1997
18589439	Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1 Chrencik, JE, Brooun, A, Zhang, H, Mathews, II, Hura, GL, Foster, SA, Perry, JJ, Streiff, M, Ramage, P, Widmer, H, Bokoch, GM, Tainer, JA, Weckbecker, G, Kuhn, P	J Mol Biol	2008