VAV3 is a GEF for Rho/Rac family kinases

Stable Identifier
R-HSA-442314
Type
Reaction
Species
Homo sapiens
Compartment
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Vav3 is a guanine nucleotide exchange factors (GEF) for RhoA, RhoB and to a lesser extent Rac1.

Literature References
PubMed ID Title Journal Year
8990121 Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Ostrom, AA, Bustelo, XR, Gutkind, JS, Crespo, P, Schuebel, KE

Nature 1997
18589439 Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1

Kuhn, P, Tainer, JA, Streiff, M, Zhang, H, Widmer, H, Hura, GL, Chrencik, JE, Perry, JJ, Bokoch, GM, Brooun, A, Ramage, P, Foster, SA, Weckbecker, G, Mathews, II

J Mol Biol 2008
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-Y173-VAV3 [cytosol]

Orthologous Events
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