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p-Y172-VAV2 [cytosol]
Stable Identifier
R-HSA-442307
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-VAV2(Y172)
Locations in the PathwayBrowser for interactor UniProt:O75674 TM1L1
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Signal transduction by L1 (Homo sapiens)
Activation of Rac1 by VAV2 (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Phosphorylation of VAV2 (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
VAV2 is a GEF for Rho/Rac family kinases (Homo sapiens)
p-Y172-VAV2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52735 VAV2
Gene Names
VAV2
Chain
chain:1-878
Reference Genes
BioGPS Gene:7410 VAV2
COSMIC (genes):VAV2 VAV2
CTD Gene:7410 VAV2
dbSNP Gene:7410 VAV2
ENSEMBL:ENSG00000160293 VAV2
HGNC:12658 VAV2
KEGG:hsa:7410 VAV2
Monarch:7410 VAV2
NCBI Gene:7410 VAV2
OMIM:600428 VAV2
UCSC:P52735 VAV2
Reference Transcript
RefSeq:NM_001411028.1 VAV2
RefSeq:XM_005272213.1 VAV2
RefSeq:NM_003371.3 VAV2
RefSeq:NM_001134398.2 VAV2
Participates
as an output of
Phosphorylation of VAV2 (Homo sapiens)
as a member of
p-Y172-VAV2,p-Y173-VAV3 [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
p-VAV family [cytosol] (Homo sapiens)
Other forms of this molecule
VAV2 [cytosol]
Inferred To
phospho-p-Y172-VAV2 [cytosol]
(Canis familiaris)
phospho-p-Y172-VAV2 [cytosol]
(Gallus gallus)
phospho-Vav [cytosol]
(Drosophila melanogaster)
phospho-vav-1 [cytosol]
(Caenorhabditis elegans)
phospho-Vav2 [cytosol]
(Mus musculus)
phospho-Vav2 [cytosol]
(Rattus norvegicus)
phospho-VAV2 [cytosol]
(Bos taurus)
phospho-VAV2 [cytosol]
(Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 172
Coordinate
172
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_003362.2
,
XP_005272270.1
,
NP_001397957.1
,
NP_001127870.1
OpenTargets
ENSG00000160293
ENSEMBL
ENSP00000360917
,
ENSP00000385362
,
ENST00000406606
,
ENST00000371851
,
ENST00000371850
,
ENSG00000160293
,
ENSP00000360916
HPA
ENSG00000160293-VAV2
GeneCards
VAV2
PRO
P52735
Pharos - Targets
P52735
GlyGen
P52735
PDB
2DLZ
,
2LNW
,
2DM1
,
2LNX
,
7WFY
,
4ROJ
,
7RNV
HMDB Protein
HMDBP10954
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P78314 3BP2
0.67
4
UniProt:Q9H3M7 TXNIP
2
TXNIP [cytosol]
(R-HSA-1250246)
TXNIP [nucleoplasm]
(R-HSA-9617747)
0.558
2
UniProt:Q8WZ42 TTN
2
TTN [cytosol]
(R-HSA-350726)
TTN [extracellular region]
(R-HSA-350729)
0.553
2
UniProt:O75674 TM1L1
0.508
2
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
CAV1 [early endosome membrane]
(R-HSA-5368451)
0.499
2
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