VAV2 is a GEF for Rho/Rac family kinases

Stable Identifier
R-HSA-442291
Type
Reaction
Species
Homo sapiens
Compartment
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Members of the Vav family are guanine nucleotide exchange factors (GEFs) for Rho-family GTPases. Vav2 is a GEF for RhoA, RhoB and RhoG, and possibly Rac1 and Cdc42

Literature References
PubMed ID Title Journal Year
8990121 Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Ostrom, AA, Bustelo, XR, Gutkind, JS, Crespo, P, Schuebel, KE

Nature 1997
18589439 Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1

Kuhn, P, Tainer, JA, Streiff, M, Zhang, H, Widmer, H, Hura, GL, Chrencik, JE, Perry, JJ, Bokoch, GM, Brooun, A, Ramage, P, Foster, SA, Weckbecker, G, Mathews, II

J Mol Biol 2008
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-Y172-VAV2 [cytosol]

Orthologous Events
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