Reactome | VAV2 is a GEF for Rho/Rac family kinases

VAV2 is a GEF for Rho/Rac family kinases

Stable Identifier

R-HSA-442291

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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VAV2 is a GEF for Rho/Rac family kinases

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Members of the Vav family are guanine nucleotide exchange factors (GEFs) for Rho-family GTPases. Vav2 is a GEF for RhoA, RhoB and RhoG, and possibly Rac1 and Cdc42

Literature References

PubMed ID	Title	Journal	Year
8990121	Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product Ostrom, AA, Bustelo, XR, Gutkind, JS, Crespo, P, Schuebel, KE	Nature	1997
18589439	Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1 Kuhn, P, Tainer, JA, Streiff, M, Zhang, H, Widmer, H, Hura, GL, Chrencik, JE, Perry, JJ, Bokoch, GM, Brooun, A, Ramage, P, Foster, SA, Weckbecker, G, Mathews, II	J Mol Biol	2008