Reactome | SRC1-1 binds SH2D2A and is recruited to VEGFR2

SRC1-1 binds SH2D2A and is recruited to VEGFR2

Stable Identifier

R-HSA-4420140

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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SRC1-1 binds SH2D2A and is recruited to VEGFR2

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SH2D2A (also known as TSAD) bound to VEGFR2 forms a complex with Src to regulate stress fiber formation and endothelial cell (EC) migration. This contributes to EC migration during pathological angiogenesis and thus the recruitment of SH2D2A is associated with cancer angiogenesis (Matsumoto et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
22689825	VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd Abid, MR, Gualandi, L, Gustafsson, K, Li, X, Sun, Z, Claesson-Welsh, L, Sundvold-Gjerstad, V, Massena, S, Jansson, L, Choy, WW, Spurkland, A, Zang, G, Quach, M, Padhan, N, Kutschera, S, Phillipson, M	J. Exp. Med.	2012