SRC1-1 binds SH2D2A and is recruited to VEGFR2

Stable Identifier
R-HSA-4420140
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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SRC1-1 binds SH2D2A and is recruited to VEGFR2
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SH2D2A (also known as TSAD) bound to VEGFR2 forms a complex with Src to regulate stress fiber formation and endothelial cell (EC) migration. This contributes to EC migration during pathological angiogenesis and thus the recruitment of SH2D2A is associated with cancer angiogenesis (Matsumoto et al. 2005).

Literature References
PubMed ID Title Journal Year
22689825 VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd

Sun, Z, Li, X, Massena, S, Kutschera, S, Padhan, N, Gualandi, L, Sundvold-Gjerstad, V, Gustafsson, K, Choy, WW, Zang, G, Quach, M, Jansson, L, Phillipson, M, Abid, MR, Spurkland, A, Claesson-Welsh, L

J. Exp. Med. 2012
Participants
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Orthologous Events
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SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Mus musculus)
SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Rattus norvegicus)
SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Sus scrofa)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Ballmer-Hofer, K  (2014-05-12)
Created
Garapati, P V  (2013-08-30)