IP3 promotes the release of intracellular calcium after initiation of WNT signaling. As a downstream consequence of WNT ligand binding, cytosolic cGMP levels decrease, reducing the activity of PKG and relieving its repression of the IP3 receptor. Subsequent binding of IP3 to the receptor allows efflux of the intracellular calcium from the endoplasmic reticulum (Ahumada et al, 2002; Ma and Yang, 2006; reviewed in Hoffman, 2005).
Ahumada, A, Slusarski, DC, Liu, X, Moon, RT, Malbon, CC, Wang, HY
Hofmann, F
Ma, L, Wang, HY
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