Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT

Stable Identifier
R-HSA-4420052
Type
Reaction
Species
Homo sapiens
Compartment
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IP3 promotes the release of intracellular calcium after initiation of WNT signaling. As a downstream consequence of WNT ligand binding, cytosolic cGMP levels decrease, reducing the activity of PKG and relieving its repression of the IP3 receptor. Subsequent binding of IP3 to the receptor allows efflux of the intracellular calcium from the endoplasmic reticulum (Ahumada et al, 2002; Ma and Yang, 2006; reviewed in Hoffman, 2005).

Literature References
PubMed ID Title Journal Year
15545263 The biology of cyclic GMP-dependent protein kinases

Hofmann, F

J Biol Chem 2005
12471263 Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP

Wang, HY, Liu, X, Slusarski, DC, Malbon, CC, Ahumada, A, Moon, RT

Science 2002
16920709 Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway

Wang, HY, Ma, L

J. Biol. Chem. 2006
Participants
Participates
Catalyst Activity

cation channel activity of ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]

Inferred From
Cross References
Rhea
Authored
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