Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT

Stable Identifier
R-HSA-4420052
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
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Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT
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IP3 promotes the release of intracellular calcium after initiation of WNT signaling. As a downstream consequence of WNT ligand binding, cytosolic cGMP levels decrease, reducing the activity of PKG and relieving its repression of the IP3 receptor. Subsequent binding of IP3 to the receptor allows efflux of the intracellular calcium from the endoplasmic reticulum (Ahumada et al, 2002; Ma and Yang, 2006; reviewed in Hoffman, 2005).

Literature References
PubMed ID Title Journal Year
12471263 Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP

Ahumada, A, Slusarski, DC, Liu, X, Moon, RT, Malbon, CC, Wang, HY

Science 2002
15545263 The biology of cyclic GMP-dependent protein kinases

Hofmann, F

J Biol Chem 2005
16920709 Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway

Ma, L, Wang, HY

J. Biol. Chem. 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cation channel activity of ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
Physical Entity
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
Activity
cation channel activity (0005261)
Inferred From
Calcium release from intracellular stores by IP3 receptor activation (Rattus norvegicus)
Cross References
Rhea
Authored
Rothfels, K  (2013-08-29)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-08-30)