Reactome | DHDDS [endoplasmic reticulum membrane]

DHDDS [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-4419977

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Dehydrodolichyl diphosphate synthase, DHDDS_HUMAN

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of dolichyl-phosphate (Homo sapiens)
        
        DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Homo sapiens)
        
        DHDDS:NUS1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        DHDDS [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86SQ9 DHDDS

Gene Names

DHDDS, HDS

Chain

chain:1-333

Reference Genes

BioGPS Gene:79947 DHDDS

COSMIC (genes):DHDDS DHDDS

CTD Gene:79947 DHDDS

dbSNP Gene:79947 DHDDS

ENSEMBL:ENSG00000117682 DHDDS

HGNC:20603 DHDDS

KEGG:hsa:79947 DHDDS

Monarch:79947 DHDDS

NCBI Gene:79947 DHDDS

OMIM:608172 DHDDS

UCSC:Q86SQ9 DHDDS

Reference Transcript

Other Identifiers

11736216_a_at

11746184_a_at

16661164

16661192

218547_PM_at

218547_at

224064_PM_s_at

224064_s_at

2326497

2326498

2326499

2326500

2326501

2326502

2326504

2326505

2326507

2326508

2326509

2326510

2326511

2326512

2326513

2326514

2326515

2326517

2326519

2326521

2326522

2326523

2326532

2326533

2326534

2326535

2326536

2326537

2326538

2326539

2326540

2326541

2326542

2326543

2326544

2326545

75091_at

76594_at

7899173

7899187

79947

87484_at

A_14_P101569

A_14_P123708

A_14_P139782

A_23_P201764

A_24_P179769

A_24_P76805

A_33_P3340792

A_33_P3340802

GE82984

GE88684

GO:0002094

GO:0003824

GO:0005515

GO:0005783

GO:0005789

GO:0006486

GO:0006489

GO:0006629

GO:0016020

GO:0016094

GO:0016740

GO:0016765

GO:0043226

GO:0045547

GO:0046872

GO:1904423

HMNXSV003023537

HMNXSV003026748

HMNXSV003051225

ILMN_1776879

ILMN_1789535

ILMN_2405642

PH_hs_0024103

TC01000344.hg

g13278671_3p_a_at

g13376336_3p_at

Participates

as a component of

DHDDS:NUS1 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

DHDDS K42E [endoplasmic reticulum membrane]

Inferred To

dhdds [endoplasmic reticulum membrane] (Danio rerio)

Dhdds [endoplasmic reticulum membrane] (Drosophila melanogaster)

Dhdds [endoplasmic reticulum membrane] (Rattus norvegicus)

RER2 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

DHDDS [endoplasmic reticulum membrane] (Bos taurus)

DHDDS [endoplasmic reticulum membrane] (Caenorhabditis elegans)

DHDDS [endoplasmic reticulum membrane] (Canis familiaris)

DHDDS [endoplasmic reticulum membrane] (Dictyostelium discoideum)

DHDDS [endoplasmic reticulum membrane] (Gallus gallus)

DHDDS [endoplasmic reticulum membrane] (Mus musculus)

DHDDS [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

DHDDS [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

OpenTargets

ENSG00000117682

ENSEMBL

ENSP00000434984, ENSG00000117682, ENSP00000353104, ENSP00000236342, ENST00000360009, ENSP00000434219, ENST00000526219, ENST00000525682, ENST00000528557, ENSP00000515248, ENST00000236342

IntEnz

2.5.1.87

HPA

ENSG00000117682-DHDDS

GeneCards

DHDDS

PRO

Q86SQ9

Pharos - Targets

Q86SQ9

Orphanet

DHDDS

PDB

7PB0, 6W2L, 7PB1, 7PAY, 7PAX, 6Z1N

HMDB Protein

HMDBP09221