TCF/LEF:CTNNB1 bind the AXIN2 gene

Stable Identifier
R-HSA-4411351
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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All four vertebrate TCF/LEF proteins have been demonstrated to bind to the AXIN2 gene in vivo and to mediate beta-catenin dependent transcription (Leung et al, 2002; Jho et al, 2002; Lustig et al, 2002, Wohrle et al, 2007; Park et al, 2009)

Literature References
PubMed ID Title Journal Year
11809809 Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

Lustig, B, Jerchow, B, Sachs, M, Weiler, S, Pietsch, T, Karsten, U, van De Wetering, M, Clevers, HC, Schlag, PM, Birchmeier, W, Behrens, J

Mol. Cell. Biol. 2002
17923689 Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors

Wöhrle, S, Wallmen, B, Hecht, A

Mol. Cell. Biol. 2007
11809808 Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

Jho, EH, Zhang, T, Domon, C, Joo, CK, Freund, JN, Costantini, F

Mol. Cell. Biol. 2002
19571879 Telomerase modulates Wnt signalling by association with target gene chromatin

Park, JI, Venteicher, AS, Hong, JY, Choi, J, Jun, S, Shkreli, M, Chang, W, Meng, Z, Cheung, P, Ji, H, McLaughlin, M, Veenstra, TD, Nusse, R, McCrea, PD, Artandi, SE

Nature 2009
11940574 Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

Leung, JY, Kolligs, FT, Wu, R, Zhai, Y, Kuick, R, Hanash, S, Cho, KR, Fearon, ER

J. Biol. Chem. 2002
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