NOTCH1 PEST domain mutants bind promoters of HEY genes

Stable Identifier
R-HSA-4396402
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH1 PEST domain mutants bind promoters of HEY genes
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NICD1 PEST domain mutant coactivator complexes are expected to bind promoters of HEY genes (HEY1, HEY2 and HEYL) in a similar manner to the wild-type NOTCH1 Coactivator Complex (Maier and Gessler 2000, Arnett et al. 2010).
Literature References
PubMed ID Title Journal Year
20972443 Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

McArthur, DG, Kopan, R, Blacklow, SC, Arnett, KL, Hass, M, Aster, JC, Ilagan, MXG

Nat Struct Mol Biol 2010
10964718 Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

Gessler, M, Maier, MM

Biochem Biophys Res Commun 2000
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as an event of
Normal reaction
NOTCH1 Coactivator Complex binds promoters of HEY genes (Homo sapiens)
Functional status

Gain of function of NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2013-08-23)
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