NOTCH1 PEST domain mutants bind HES1 promoter

Stable Identifier
R-HSA-4396392
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
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NICD1 PEST domain mutants-containing coactivator complexes are expected to bind HES1 promoter in a similar manner to the wild-type NOTCH1 Coactivator Complex (Jarriault et al. 1995).
Literature References
PubMed ID Title Journal Year
7566092 Signalling downstream of activated mammalian Notch

Kopan, R, Schroeter, EH, Brou, C, Israel, A, Jarriault, S, Logeat, F

Nature 1995
Participants
Participates
Normal reaction
Functional status

Gain of function of NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Reviewed
Created
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