CCND1:CREBBP binds NOTCH1 promoter

Stable Identifier
R-HSA-4395227
Type
Reaction [binding]
Species
Homo sapiens
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CCND1 (cyclin D1) forms a complex with CREBBP and binds to the NOTCH1 promoter, stimulating NOTCH1 transcription. The involvement of CCND1 in transcriptional regulation of NOTCH1 was established in mouse retinas and the rat retinal precursor cell line R28 (Bienvenu et al. 2010).

Literature References
PubMed ID Title Journal Year
20090754 Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen

Bienvenu, F, Jirawatnotai, S, Elias, JE, Meyer, CA, Mizeracka, K, Marson, A, Frampton, GM, Cole, MF, Odom, DT, Odajima, J, Geng, Y, Zagozdzon, A, Jecrois, M, Young, RA, Liu, XS, Cepko, CL, Gygi, SP, Sicinski, P

Nature 2010
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