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Post NMDA receptor activation events
Stable Identifier
R-HSA-438064
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
nucleoplasm
ReviewStatus
5/5
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
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Ca2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca2+ within the spine leads to phosphorylation of Cyclic AMP Response Element binding protein (CREB1) at serine S133, leading to transcription of genes involved in long lasting changes at the synapse. The phosphorylation of CREB1 triggered by increased Ca2+ can be brought about by distinct molecular pathways that may involve MAP kinase, activation of adenylate cyclase and activation of CaMKIV (reviewed by Cohen and Greenberg 2008 and Hunt and Castillo 2012).
Literature References
PubMed ID
Title
Journal
Year
22325859
Synaptic plasticity of NMDA receptors: mechanisms and functional implications
Castillo, PE
,
Hunt, DL
Curr. Opin. Neurobiol.
2012
18616423
Communication between the synapse and the nucleus in neuronal development, plasticity, and disease
Cohen, S
,
Greenberg, ME
Annu Rev Cell Dev Biol
2008
Participants
Events
Long-term potentiation
(Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
(Homo sapiens)
CREB1 phosphorylation through the activation of Adenylate Cyclase
(Homo sapiens)
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
(Homo sapiens)
Activation of RAC1 downstream of NMDARs
(Homo sapiens)
Activation of AMPK downstream of NMDARs
(Homo sapiens)
Participates
as an event of
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Orthologous Events
Post NMDA receptor activation events (Bos taurus)
Post NMDA receptor activation events (Caenorhabditis elegans)
Post NMDA receptor activation events (Canis familiaris)
Post NMDA receptor activation events (Danio rerio)
Post NMDA receptor activation events (Dictyostelium discoideum)
Post NMDA receptor activation events (Drosophila melanogaster)
Post NMDA receptor activation events (Gallus gallus)
Post NMDA receptor activation events (Mus musculus)
Post NMDA receptor activation events (Plasmodium falciparum)
Post NMDA receptor activation events (Rattus norvegicus)
Post NMDA receptor activation events (Saccharomyces cerevisiae)
Post NMDA receptor activation events (Schizosaccharomyces pombe)
Post NMDA receptor activation events (Sus scrofa)
Post NMDA receptor activation events (Xenopus tropicalis)
Authored
Mahajan, SS (2009-10-29)
Reviewed
Tukey, D (2009-11-18)
Hansen, KB (2018-11-02)
Yi, F (2018-11-02)
Created
Mahajan, SS (2009-09-23)
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