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What is Reactome ?
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Table of Contents
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FAQ
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Analyse gene expression
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p-Y348-SYK [cytosol]
Stable Identifier
R-HSA-437953
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-SYK(Y348), Tyrosine-protein kinase SYK , Spleen tyrosine kinase
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9ULZ3 PYCARD
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
Syk activation leads to SLP-76 activation (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
p-Y348-SYK binds VAV family (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
p-Y348-SYK dissociates (Homo sapiens)
p-Y348-SYK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43405 SYK
Gene Names
SYK
Chain
chain:1-635
Reference Genes
BioGPS Gene:6850 SYK
COSMIC (genes):SYK SYK
CTD Gene:6850 SYK
dbSNP Gene:6850 SYK
ENSEMBL:ENSG00000165025 SYK
ENSEMBL_homo_sapiens_GENE:ENSG00000165025.15 SYK
HGNC:11491 SYK
KEGG Gene (Homo sapiens):6850 SYK
Monarch:6850 SYK
NCBI Gene:6850 SYK
OMIM:600085 SYK
UCSC:P43405 SYK
Reference Transcript
RefSeq:NM_003177.6 SYK
RefSeq:NM_001174168.2 SYK
RefSeq:XM_011518946.2 SYK
RefSeq:NM_001174167.2 SYK
RefSeq:XM_005252147.3 SYK
RefSeq:NM_001135052.3 SYK
Other Identifiers
11719718_a_at
11754925_a_at
1630_s_at
17086708
207540_PM_s_at
207540_s_at
209269_PM_s_at
209269_s_at
226068_PM_at
226068_at
3178954
3178955
3178958
3178959
3178960
3178961
3178964
3178965
3178969
3178971
3178972
3178973
3178977
3178980
3178982
3178984
3178986
3178989
3178994
3178995
3178996
3178997
3178998
36885_at
548_s_at
55564_at
6850
7896689
7896705
8156321
A_14_P110676
A_14_P117239
A_23_P9255
GE57710
GO:0000166
GO:0001525
GO:0001775
GO:0001784
GO:0001819
GO:0001820
GO:0001945
GO:0002092
GO:0002223
GO:0002250
GO:0002281
GO:0002283
GO:0002366
GO:0002376
GO:0002554
GO:0002696
GO:0002862
GO:0003824
GO:0004672
GO:0004674
GO:0004713
GO:0004715
GO:0005102
GO:0005178
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0006954
GO:0007155
GO:0007159
GO:0007166
GO:0007167
GO:0007169
GO:0007229
GO:0009887
GO:0010543
GO:0010803
GO:0012501
GO:0016020
GO:0016170
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019370
GO:0019722
GO:0019815
GO:0019901
GO:0019902
GO:0023052
GO:0030154
GO:0030168
GO:0030183
GO:0030593
GO:0031234
GO:0031334
GO:0031410
GO:0031623
GO:0032009
GO:0032481
GO:0032725
GO:0032733
GO:0032735
GO:0032752
GO:0032753
GO:0032755
GO:0032757
GO:0032760
GO:0032765
GO:0032928
GO:0032930
GO:0032991
GO:0033630
GO:0035325
GO:0035556
GO:0036211
GO:0038063
GO:0038095
GO:0038096
GO:0038156
GO:0042060
GO:0042101
GO:0042169
GO:0042492
GO:0042742
GO:0043226
GO:0043274
GO:0043280
GO:0043303
GO:0043306
GO:0043313
GO:0043366
GO:0043410
GO:0045087
GO:0045579
GO:0045588
GO:0045780
GO:0046638
GO:0046641
GO:0048514
GO:0048856
GO:0048870
GO:0050731
GO:0050764
GO:0050778
GO:0050850
GO:0050853
GO:0051090
GO:0051649
GO:0051712
GO:0065003
GO:0070372
GO:0071226
GO:0071396
GO:0071404
GO:0071639
GO:0090237
GO:0090330
GO:0097110
GO:0098542
GO:0120162
GO:0140096
GO:1904263
GO:1990858
HMNXSV003042953
Hs.74101.1.S2_3p_a_at
Hs.74101.2.S1_3p_a_at
Hs.74101.2.S1_3p_at
ILMN_2059549
PH_hs_0022924
S80267_s_at
TC09000428.hg
g4507328_3p_a_at
Participates
as a member of
p-Y348-SYK/LCK [cytosol] (Homo sapiens)
as an input of
p-Y348-SYK binds VAV family (Homo sapiens)
as a component of
p-Y348-SYK:p-VAV family [cytosol] (Homo sapiens)
p-Y348-SYK:VAV family [cytosol] (Homo sapiens)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
as an output of
p-Y348-SYK dissociates (Homo sapiens)
Other forms of this molecule
p-Y-SYK [cytosol]
p-Y-SYK [plasma membrane]
SYK [plasma membrane]
p-6Y-SYK [cytosol]
SYK [cytosol]
Inferred To
phospho-p-Y348-SYK [cytosol]
(Drosophila melanogaster)
phospho-p-Y348-SYK [cytosol]
(Gallus gallus)
phospho-p-Y348-SYK [cytosol]
(Mus musculus)
phospho-p-Y348-SYK [cytosol]
(Rattus norvegicus)
phospho-p-Y348-SYK [cytosol]
(Sus scrofa)
phospho-p-Y348-SYK [cytosol]
(Xenopus tropicalis)
phospho-SYK [cytosol]
(Bos taurus)
phospho-SYK [cytosol]
(Canis familiaris)
Modified Residues
Name
O4'-phospho-L-tyrosine at 348
Coordinate
348
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_005252204.1
,
NP_001128524.1
,
NP_003168.2
,
XP_011517248.1
,
NP_001167639.1
,
NP_001167638.1
ZINC - World Drugs
KSYK_HUMAN
Guide to Pharmacology - Targets
2230
OpenTargets
ENSG00000165025
ZINC - FDA approved
KSYK_HUMAN
ZINC - Substances
KSYK_HUMAN
ZINC - Biogenic
KSYK_HUMAN
ZINC target
P43405
PRO
P43405
PDB
4YJU
,
3VF9
,
4DFN
,
3TUD
,
4XG6
,
4YJQ
,
6ZCY
,
7SA7
,
5Y5T
,
4XG7
,
4PUZ
,
4PV0
,
4DFL
,
4YJV
,
1XBC
,
3FQH
,
4RX9
,
3TUC
,
5C26
,
4XG2
,
8RRQ
,
4YJR
,
4F4P
,
4PX6
,
6ZCP
,
4YJS
,
5CXH
,
1XBB
,
6ZCU
,
4FL3
,
4RSS
,
4I0S
,
6HM6
,
7Q5U
,
6ZCQ
,
4XG4
,
3EMG
,
4YJO
,
4FL2
,
6ZC0
,
5LMA
,
4I0T
,
4FZ7
,
4WNM
,
5TIU
,
6VOV
,
5CY3
,
4RX8
,
5CXZ
,
5T68
,
4FL1
,
7Q5W
,
5LMB
,
5TR6
,
6HM7
,
8BI2
,
6ZCR
,
5TT7
,
3VF8
,
8RRZ
,
8X5K
,
7Q63
,
6ZCS
,
4XG8
,
5Y5U
,
7Q5T
,
1XBA
,
4FYO
,
1CSZ
,
4I0R
,
3FQE
,
3TUB
,
6SSB
,
4XG3
,
1A81
,
5C27
,
5GHV
,
4FYN
,
4YJT
,
4FZ6
,
4XG9
,
4GFG
,
1CSY
,
6ZCX
,
4RX7
,
3FQS
,
4YJP
,
3BUW
,
3SRV
ZINC - Investigational
KSYK_HUMAN
ZINC - Metabolites
KSYK_HUMAN
HPA
ENSG00000165025-SYK
GeneCards
P43405
Ensembl
ENSP00000364904
,
ENSP00000364907
,
ENST00000375746
,
ENST00000375754
,
ENSP00000364898
,
ENSP00000364899
,
ENST00000375751
,
ENST00000375747
,
ENSG00000165025
Pharos - Targets
P43405
ZINC - Predictions - Purchasable
KSYK_HUMAN
HMDB Protein
HMDBP01458
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.873
10
UniProt:Q9UHP3 USP25
1
USP25 [cytosol]
(R-HSA-5696900)
0.831
8
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.748
8
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.743
7
UniProt:P36888 FLT3
20
FLT3 F691I [plasma membrane]
(R-HSA-9702900)
FLT3 N676D [plasma membrane]
(R-HSA-9702895)
FLT3 R834Q [plasma membrane]
(R-HSA-9691899)
FLT3 Y572C [plasma membrane]
(R-HSA-9691902)
FLT3 A848P [plasma membrane]
(R-HSA-9702909)
FLT3 A627P [plasma membrane]
(R-HSA-9699448)
FLT3 F621L [plasma membrane]
(R-HSA-9699426)
p-Y768,Y969 FLT3 [plasma membrane]
(R-HSA-9698405)
Ub-pY FLT3 [endosome membrane]
(R-HSA-9706174)
Ub-pY FLT3 [plasma membrane]
(R-HSA-9706171)
FLT3 V592G [plasma membrane]
(R-HSA-9691071)
FLT3 F590_F605dup [plasma membrane]
(R-HSA-9697939)
FLT3 F590G Y591D [plasma membrane]
(R-HSA-9691062)
FLT3 F594L [plasma membrane]
(R-HSA-9691058)
FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]
(R-HSA-9699433)
FLT3 V579A [plasma membrane]
(R-HSA-9691051)
FLT3 Y599_D600insGLYVDFREYEY [plasma membrane]
(R-HSA-9696044)
FLT3 Y591_V592insVDFREDREHH [plasma membrane]
(R-HSA-9696043)
FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane]
(R-HSA-9690076)
FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane]
(R-HSA-9696033)
0.737
22
UniProt:P20273 CD22
3
NAc-CD22 [plasma membrane]
(R-HSA-5690736)
CD22 [plasma membrane]
(R-HSA-197703)
p-Y762,807,822-CD22 [plasma membrane]
(R-HSA-5690726)
0.623
4
UniProt:P07766 CD3E
2
CD3E [plasma membrane]
(R-HSA-197906)
p-Y188,Y199-CD3E [plasma membrane]
(R-HSA-202228)
0.597
6
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
0.591
4
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.581
5
UniProt:Q96IP4 TET5A
0.57
3
UniProt:P30273 FCER1G
5
FCER1G [ficolin-1-rich granule membrane]
(R-HSA-6801016)
FCER1G [tertiary granule membrane]
(R-HSA-6800183)
p-Y65-FCER1G [plasma membrane]
(R-HSA-2454244)
FCER1G [plasma membrane]
(R-HSA-54715)
p-Y65,Y76-FCER1G [plasma membrane]
(R-HSA-141096)
0.564
2
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.556
3
UniProt:Q8TF42 UBS3B
0.544
2
UniProt:P54274 TERF1
1
TERF1 [nucleoplasm]
(R-HSA-164618)
0.508
2
ChEBI:39112 BOSUTINIB
0.499
2
UniProt:P11049 CD37
0.499
3
ChEBI:49375 DASATINIB
0.499
2
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.462
4
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.462
3
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