p-Y348-SYK phosphorylates VAV family

Stable Identifier
R-HSA-437936
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Tyrosine phosphorylateion is believed to be a general activation mechansim for the Vav family. VAV1 Tyr-174 binds to the Dbl homology region, inhibiting GEF activity. Phosphorylation of this residue by Syk relieves inhibition, activating Vav1. In Jurkat cells T-cell receptor activation leads to increased Vav2 tyrosine phosphorylation; the expression of Lck, Fyn, Zap70, or Syk stimulated this phosphorylation. Vav is regulated downstream of the thrombin and thrombopoietin receptors (Miyakawa et al. 1997) and integrins, including the major platelet integrin alphaIIbbeta3. Vav family proteins are involved in filopodia and lamellipodia formation; mouse platelets deficient in Vav1 and Vav3 exhibit reduced filopodia and lamellipodia formation during spreading on fibrinogen. This is accompanied by reduced alphaIIbbeta3-mediated PLCgamma2 tyrosine phosphorylation and reduced Ca(2+) mobilization (Pearce et al. 2007).

Literature References
PubMed ID Title Journal Year
8986718 Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

Deckert, M, Tartare-Deckert, S, Couture, C, Mustelin, T, Altman, A

Immunity 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine kinase activity of p-Y348-SYK:VAV family [cytosol]
Physical Entity
Activity
Inferred From
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Created