Reactome | ZnT8 transports zinc into the Golgi apparatus

ZnT8 transports zinc into the Golgi apparatus

Stable Identifier

R-HSA-437139

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

ZnT8 transports zinc into the Golgi apparatus

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dimeric ZnT8/SLC30A8 mediates the transport of cytosolic Zn2+ into the lumen of the Golgi apparatus. The protein is expressed in human pancreatic beta cells and localizes with the Golgi apparatus and insulin-containing secretory granules (Bosco et al. 2010; Chimienti et al. 2006; Kambe et al. 2021; Chimienti et al., 2004). SLC30A8 utilizes the antiport of two protons to achieve electroneutral transport (Xue et al., 2020).

Literature References

PubMed ID	Title	Journal	Year
21713314	Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation Bosco, MD, Mohanasundaram, DM, Drogemuller, CJ, Lang, CJ, Zalewski, PD, Coates, PT	Rev Diabet Stud	2010
33485965	Zinc transporters and their functional integration in mammalian cells Kambe, T, Taylor, KM, Fu, D	J Biol Chem	2021
32723473	Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations Xue, J, Xie, T, Zeng, W, Jiang, Y, Bai, XC	Elife	2020
15331542	Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules Chimienti, F, Devergnas, S, Favier, A, Seve, M	Diabetes	2004
16984975	In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion Chimienti, F, Devergnas, S, Pattou, F, Schuit, F, Garcia-Cuenca, R, Vandewalle, B, Kerr-Conte, J, Van Lommel, L, Grunwald, D, Favier, A, Seve, M	J Cell Sci	2006