Reactome | ZnT1 mediates the efflux of zinc from the cell

ZnT1 mediates the efflux of zinc from the cell

Stable Identifier

R-HSA-435366

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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ZnT1 mediates the efflux of zinc from the cell

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The human gene SLC30A1 encodes the zinc transporter ZnT1. It is widely expressed throughout the body and it's expression is regulated by zinc. ZnT1 is the only member of the SLC30 gene family that is located on the plasma membrane and mediates the transport of zinc out of the cell (Devergnas S et al, 2004) using a proton antiport mechanism (Nishito & Kambe et al., 2019).

Literature References

PubMed ID	Title	Journal	Year
31471319	Zinc transporter 1 (ZNT1) expression on the cell surface is elaborately controlled by cellular zinc levels Nishito, Y, Kambe, T	J Biol Chem	2019
15276077	Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study Devergnas, S, Chimienti, F, Naud, N, Pennequin, A, Coquerel, Y, Chantegrel, J, Favier, A, Seve, M	Biochem Pharmacol	2004