Reactome | ZnT1 mediates the efflux of zinc from the cell

ZnT1 mediates the efflux of zinc from the cell

Stable Identifier

R-HSA-435366

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc efflux and compartmentalization by the SLC30 family (Homo sapiens)
        
        ZnT1 mediates the efflux of zinc from the cell (Homo sapiens)

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ZnT1 mediates the efflux of zinc from the cell

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The human gene SLC30A1 encodes the zinc transporter ZnT1. It is widely expressed throughout the body and it's expression is regulated by zinc. ZnT1 is the only member of the SLC30 gene family that is located on the plasma membrane and mediates the transport of zinc out of the cell (Devergnas S et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
15276077	Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study Coquerel, Y, Chantegrel, J, Seve, M, Favier, A, Devergnas, S, Chimienti, F, Naud, N, Pennequin, A	Biochem Pharmacol	2004