Reactome | SLC30A1 [plasma membrane]

SLC30A1 [plasma membrane]

Stable Identifier

R-HSA-435361

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ZnT1, Zinc transporter 1, ZNT1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P43119 PTGIR

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Metal ion SLC transporters (Homo sapiens)
      - Zinc transporters (Homo sapiens)
        
        Zinc efflux and compartmentalization by the SLC30 family (Homo sapiens)
        
        ZnT1 mediates the efflux of zinc from the cell (Homo sapiens)
        
        SLC30A1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y6M5 SLC30A1

Gene Names

SLC30A1, ZNT1

Chain

chain:1-507

Reference Genes

BioGPS Gene:7779 SLC30A1

COSMIC (genes):SLC30A1 SLC30A1

CTD Gene:7779 SLC30A1

dbSNP Gene:7779 SLC30A1

ENSEMBL:ENSG00000170385 SLC30A1

ENSEMBL_homo_sapiens_GENE:ENSG00000170385.10 SLC30A1

HGNC:11012 SLC30A1

KEGG Gene (Homo sapiens):7779 SLC30A1

Monarch:7779 SLC30A1

NCBI Gene:7779 SLC30A1

OMIM:609521 SLC30A1

UCSC:Q9Y6M5 SLC30A1

Reference Transcript

RefSeq:NM_021194.2 SLC30A1

Other Identifiers

11726006_at

11758948_s_at

16698980

212907_PM_at

212907_at

228181_PM_at

228181_at

2454379

2454380

2454381

2454382

2454386

2454387

2454388

2454389

2454390

2454391

34759_at

57607_at

7779

7924092

A_23_P23815

A_24_P937095

GE59361

GE61998

GO:0001701

GO:0005215

GO:0005385

GO:0005515

GO:0005634

GO:0005635

GO:0005737

GO:0005783

GO:0005794

GO:0005886

GO:0006811

GO:0006812

GO:0006829

GO:0006874

GO:0006882

GO:0008324

GO:0010312

GO:0015297

GO:0016020

GO:0016323

GO:0019855

GO:0023052

GO:0030315

GO:0030659

GO:0031410

GO:0031965

GO:0042742

GO:0043226

GO:0046872

GO:0046929

GO:0048856

GO:0055065

GO:0055085

GO:0062111

GO:0070509

GO:0070574

GO:0071577

GO:0071584

GO:0071585

GO:0090281

GO:0098542

GO:0098685

GO:0098754

GO:0098772

GO:0098839

GO:0140826

GO:0140882

HMNXSV003056581

Hs.24385.0.S1_3p_at

Hs.55610.0.S1_3p_at

ILMN_1745021

ILMN_2067852

PH_hs_0035435

TC01003796.hg

TC01006089.hg

U68494_at

Inferred To

SLC30A1 [plasma membrane] (Bos taurus)

SLC30A1 [plasma membrane] (Canis familiaris)

SLC30A1 [plasma membrane] (Dictyostelium discoideum)

SLC30A1 [plasma membrane] (Gallus gallus)

SLC30A1 [plasma membrane] (Mus musculus)

SLC30A1 [plasma membrane] (Rattus norvegicus)

SLC30A1 [plasma membrane] (Sus scrofa)

ZRC1 [plasma membrane] (Saccharomyces cerevisiae)

zhf1 [plasma membrane] (Schizosaccharomyces pombe)

slc30a1 [plasma membrane] (Xenopus tropicalis)

cdf-1 [plasma membrane] (Caenorhabditis elegans)

ZnT77C [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_067017.2

Guide to Pharmacology - Targets

1121

OpenTargets

ENSG00000170385

GeneCards

Q9Y6M5

HPA

ENSG00000170385-SLC30A1

Ensembl

ENST00000367001, ENSP00000355968, ENSG00000170385

PRO

Q9Y6M5

Pharos - Targets

Q9Y6M5

HMDB Protein

HMDBP12036

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00214 LEG8			0.527	2
UniProt:Q8N6G5 CSGALNACT2	1	CSGALNACT2 [Golgi membrane] (R-HSA-1971506)	0.527	2
UniProt:O95661 DIRA3			0.527	3
UniProt:Q8IZF4 AGRG5			0.527	2
UniProt:Q8NCL4 GALNT6	1	GALNT6 [Golgi membrane] (R-HSA-913608)	0.527	2
UniProt:Q8TDX6 CSGALNACT1	1	CSGALNACT1 [Golgi membrane] (R-HSA-1971468)	0.527	2
UniProt:Q01151 CD83			0.527	2
UniProt:Q9UHF4 IL20RA	1	IL20RA [plasma membrane] (R-HSA-448713)	0.527	2
UniProt:Q9UGM1 CHRNA9	1	CHRNA9 [plasma membrane] (R-HSA-507827)	0.527	2
UniProt:P08842 STS	3	STS [endoplasmic reticulum lumen] (R-HSA-1614318) OxA-STS [endoplasmic reticulum lumen] (R-HSA-1614333) OxA-STS [endoplasmic reticulum membrane] (R-HSA-1606833)	0.527	2
UniProt:P43119 PTGIR	1	PTGIR [plasma membrane] (R-HSA-391834)	0.527	2
UniProt:P17931 LGALS3	3	LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307) LGALS3 [plasma membrane] (R-HSA-879445) LGALS3 [secretory granule membrane] (R-HSA-6803327)	0.527	3
UniProt:Q8TC26 TM163			0.463	3