Reactome | SEMA7A binds to PLXNC1

SEMA7A binds to PLXNC1

Stable Identifier

R-HSA-434989

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Sema7A signals through two unrelated receptors, an RGD-dependent alpha1beta1-integrin and a member of the plexin family, plexinC1. Sema7A-plexinC1 interactions have been implicated in immune system function and also participate in neuronal network formation.

Literature References

PubMed ID	Title	Journal	Year
10520995	Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates Artigiani, S, Winberg, ML, Song, H, He, Z, Poo, M, Tamagnone, L, Goodman, CS, Tessier-Lavigne, M, Comoglio, PM, Chédotal, A, Ming, GI, Chen, H	Cell	1999