PIP2 binds inhibiting VAV

Stable Identifier
R-HSA-434633
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PIP2 binds inhibiting VAV
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Vav interacts directly with PIP2 and PIP3, with a fivefold selectivity for PIP3 over PIP2. PIP3 gives a twofold stimulation of Vav1 GEF activity while PIP2 leads to 90% inhibition. Binding probably occurs through the PH domain, known to bind phosphoinositides.
Literature References
PubMed ID Title Journal Year
9438848 Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

White, MA, Falck, JR, Mosteller, RD, Xia, Y, Han, J, Shu, X, Das, B, Luby-Phelps, K, Krishna, UM, Broek, D

Science 1998
Participants
Input
Output
Participates
as an event of
Inferred From
PIP2 inhibits Vav1 (Mus musculus)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Harper, MT  (2009-11-02)
Poole, AW  (2009-11-02)
Jones, ML  (2009-11-02)
Created
Jupe, S  (2009-09-02)
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