CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol

Stable Identifier
R-HSA-434381
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
a long-chain fatty acid(out) = a long-chain fatty acid(in)
ReviewStatus
5/5
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CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol
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CD36 (FAT) located in the plasma membrane of pancreatic beta cells transports long chain fatty acids such as palmitate into the cell (Noushmehr et al. 2005).
Literature References
PubMed ID Title Journal Year
15677505 Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion

Noushmehr, H, D'Amico, E, Farilla, L, Hui, H, Wawrowsky, KA, Mlynarski, W, Doria, A, Abumrad, NA, Perfetti, R

Diabetes 2005
Participants
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as an event of
Catalyst Activity

long-chain fatty acid transmembrane transporter activity of 4xPalmC-CD36 [plasma membrane]

Physical Entity
4xPalmC-CD36 [plasma membrane] (Homo sapiens)
Activity
long-chain fatty acid transmembrane transporter activity (GO:0005324)
Orthologous Events
CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol (Bos taurus)
CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol (Canis familiaris)
CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol (Danio rerio)
CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol (Dictyostelium discoideum)
CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol (Drosophila melanogaster)
CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol (Gallus gallus)
CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol (Mus musculus)
CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol (Rattus norvegicus)
CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol (Sus scrofa)
CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol (Xenopus tropicalis)
Cross References
RHEA
Authored
May, B  (2009-08-28)
Reviewed
D'Eustachio, P  (2018-12-22)
Hill, DP  (2025-06-02)
Created
May, B  (2009-08-28)
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