SUMOylation of RARA with SUMO2

Stable Identifier
R-HSA-4341072
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SUMOylation of RARA with SUMO2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RARA (Retinoic acid receptor alpha) is SUMOylated at lysine-166, lysine-171, and lysine-399 with SUMO2 (Zhu et al. 2009). SUMOylation at lysine-166 and lysine-171 is induced by all-trans retinoic acid and inhibits nuclear localization of RARA. SUMOylation at lysine-399 is observed in the absence of all-trans retinoic acid and enhances nuclear localization of RARA. SUMOylation of all 3 sites inhibits transcriptional activation by RARA.

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

SUMO transferase activity of SUMO2:UBE2I [nucleoplasm]

Physical Entity
SUMO2:UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of RARA with SUMO2 (Bos taurus)
SUMOylation of RARA with SUMO2 (Danio rerio)
SUMOylation of RARA with SUMO2 (Drosophila melanogaster)
SUMOylation of RARA with SUMO2 (Gallus gallus)
SUMOylation of RARA with SUMO2 (Mus musculus)
SUMOylation of RARA with SUMO2 (Rattus norvegicus)
Authored
May, B  (2013-08-14)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-19)
Cite Us!