SUMOylation of RARA with SUMO2

Stable Identifier
R-HSA-4341072
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of RARA with SUMO2
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RARA (Retinoic acid receptor alpha) is SUMOylated at lysine-166, lysine-171, and lysine-399 with SUMO2 (Zhu et al. 2009). SUMOylation at lysine-166 and lysine-171 is induced by all-trans retinoic acid and inhibits nuclear localization of RARA. SUMOylation at lysine-399 is observed in the absence of all-trans retinoic acid and enhances nuclear localization of RARA. SUMOylation of all 3 sites inhibits transcriptional activation by RARA.
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Catalyst Activity

SUMO transferase activity of SUMO2:UBE2I [nucleoplasm]

Physical Entity
SUMO2:UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of RARA with SUMO2 (Bos taurus)
SUMOylation of RARA with SUMO2 (Danio rerio)
SUMOylation of RARA with SUMO2 (Drosophila melanogaster)
SUMOylation of RARA with SUMO2 (Gallus gallus)
SUMOylation of RARA with SUMO2 (Mus musculus)
SUMOylation of RARA with SUMO2 (Rattus norvegicus)
SUMOylation of RARA with SUMO2 (Sus scrofa)
Authored
May, B  (2013-08-14)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-19)
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