SUMOylation of RARA with SUMO2

Stable Identifier
R-HSA-4341072
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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SUMOylation of RARA with SUMO2
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RARA (Retinoic acid receptor alpha) is SUMOylated at lysine-166, lysine-171, and lysine-399 with SUMO2 (Zhu et al. 2009). SUMOylation at lysine-166 and lysine-171 is induced by all-trans retinoic acid and inhibits nuclear localization of RARA. SUMOylation at lysine-399 is observed in the absence of all-trans retinoic acid and enhances nuclear localization of RARA. SUMOylation of all 3 sites inhibits transcriptional activation by RARA.

Literature References
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO2:UBE2I [nucleoplasm]
Physical Entity
SUMO2:UBE2I [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Orthologous Events
SUMOylation of RARA with SUMO2 (Danio rerio)
SUMOylation of RARA with SUMO2 (Drosophila melanogaster)
SUMOylation of RARA with SUMO2 (Mus musculus)
SUMOylation of RARA with SUMO2 (Rattus norvegicus)
SUMOylation of RARA with SUMO2 (Sus scrofa)
SUMOylation of RARA with SUMO2 (Xenopus tropicalis)
Authored
May, B  (2013-08-14)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-19)
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