Reactome | Cis-homodimerization of nectins

Cis-homodimerization of nectins

Stable Identifier

R-HSA-433711

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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The Nectin family of Ca2+-independent cell adhesion molecules (CAMs) is comprised of four members, nectin-1, nectin-2, nectin-3, and nectin-4 (reviewed in Sakisaka et al., 2007). Each nectin first forms homophilic cis-dimers and then forms homophilic or heterophilic trans-dimers involved in cell–cell adhesion. Heterophilic trans-interactions are stronger than homophilic trans-interactions.

Literature References

PubMed ID	Title	Journal	Year
9845526	The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule Lopez, M, Aoubala, M, Jordier, F, Isnardon, D, Gomez, S, Dubreuil, P	Blood	1998