Reactome | CAMK2 binds MAP3K7

CAMK2 binds MAP3K7

Stable Identifier

R-HSA-4332356

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Several studies in C. elegans and vertebrates suggest that a TAK1-NLK kinase cascade regulates the activity of the canonical WNT signaling pathway (Ishitani et al, 1999; Meneghini et al, 1999; Shin et al, 1999; Rocheleau et al, 1999). Activation of this MAPK cascade depends on CAMK2 activity downstream of WNT5a non-canonical signaling (Ishitani et al, 2003a, b). CAMK2 co-precipitates with TAK1/MAP3K7 upon co-transfection in HEK293 cells and calcium signaling activates MAP3K7 in a CAMK2-dependent manner (Ishitani et al, 2003a).

Literature References

PubMed ID	Title	Journal	Year
10391246	MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans Hamill, DR, Hisamoto, N, Bowerman, B, Ishitani, T, Meneghini, MD, Thorpe, CJ, Matsumoto, K, Ninomiya-Tsuji, J, Carter, JC	Nature	1999
10488343	MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans Bei, Y, Soto, M, Shin, TH, Mello, CC, Davis, RJ, Lin, R, Rocheleau, CE, Yasuda, J	Mol. Cell	1999
12556497	Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling Ishitani, T, Matsumoto, K, Ninomiya-Tsuji, J	Mol. Cell. Biol.	2003
10380924	WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans Shin, TH, Mello, CC, Sawa, H, Davis, RJ, Priess, JR, Okano, H, Lin, R, Yasuda, J, Rocheleau, CE	Cell	1999
12482967	The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling Shibuya, H, Ishitani, T, Hyodo-Miura, J, Waterman, M, Matsumoto, K, Yasuda, J, Ninomiya-Tsuji, J, Ueno, N, Moon, RT, Kishida, S	Mol. Cell. Biol.	2003