Several studies in C. elegans and vertebrates suggest that a TAK1-NLK kinase cascade regulates the activity of the canonical WNT signaling pathway (Ishitani et al, 1999; Meneghini et al, 1999; Shin et al, 1999; Rocheleau et al, 1999). Activation of this MAPK cascade depends on CAMK2 activity downstream of WNT5a non-canonical signaling (Ishitani et al, 2003a, b). CAMK2 co-precipitates with TAK1/MAP3K7 upon co-transfection in HEK293 cells and calcium signaling activates MAP3K7 in a CAMK2-dependent manner (Ishitani et al, 2003a).
Shin, TH, Yasuda, J, Rocheleau, CE, Lin, R, Soto, M, Bei, Y, Davis, RJ, Mello, CC
Meneghini, MD, Ishitani, T, Carter, JC, Hisamoto, N, Ninomiya-Tsuji, J, Thorpe, CJ, Hamill, DR, Matsumoto, K, Bowerman, B
Ishitani, T, Ninomiya-Tsuji, J, Matsumoto, K
Rocheleau, CE, Yasuda, J, Shin, TH, Lin, R, Sawa, H, Okano, H, Priess, JR, Davis, RJ, Mello, CC
Ishitani, T, Kishida, S, Hyodo-Miura, J, Ueno, N, Yasuda, J, Waterman, M, Shibuya, H, Moon, RT, Ninomiya-Tsuji, J, Matsumoto, K
© 2021 Reactome
