Several studies in C. elegans and vertebrates suggest that a TAK1-NLK kinase cascade regulates the activity of the canonical WNT signaling pathway (Ishitani et al, 1999; Meneghini et al, 1999; Shin et al, 1999; Rocheleau et al, 1999). Activation of this MAPK cascade depends on CAMK2 activity downstream of WNT5a non-canonical signaling (Ishitani et al, 2003a, b). CAMK2 co-precipitates with TAK1/MAP3K7 upon co-transfection in HEK293 cells and calcium signaling activates MAP3K7 in a CAMK2-dependent manner (Ishitani et al, 2003a).
Hamill, DR, Hisamoto, N, Bowerman, B, Ishitani, T, Meneghini, MD, Thorpe, CJ, Matsumoto, K, Ninomiya-Tsuji, J, Carter, JC
Bei, Y, Soto, M, Shin, TH, Mello, CC, Davis, RJ, Lin, R, Rocheleau, CE, Yasuda, J
Ishitani, T, Matsumoto, K, Ninomiya-Tsuji, J
Shin, TH, Mello, CC, Sawa, H, Davis, RJ, Priess, JR, Okano, H, Lin, R, Yasuda, J, Rocheleau, CE
Shibuya, H, Ishitani, T, Hyodo-Miura, J, Waterman, M, Matsumoto, K, Yasuda, J, Ninomiya-Tsuji, J, Ueno, N, Moon, RT, Kishida, S
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